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We propose a general method for constructing confidence intervals and statistical tests for single or low-dimensional components of a large parameter vector in a high-dimensional model. It can be easily adjusted for multiplicity taking dependence among tests into account. For linear models, our method is essentially the same as in Zhang and Zhang [J. R. Stat. Soc. Ser. B Stat. Methodol. 76 (2014) 217-242]: we analyze its asymptotic properties and establish its asymptotic optimality in terms of semiparametric efficiency. Our method naturally extends to generalized linear models with convex loss functions. We develop the corresponding theory which includes a careful analysis for Gaussian, sub-Gaussian and bounded correlated designs.

In clinical studies, when censoring is caused by competing risks or patient withdrawal, there is always a concern about the validity of treatment effect estimates that are obtained under the assumption of independent censoring. Because dependent censoring is nonidentifiable without additional information, the best we can do is a sensitivity analysis to assess the changes of parameter estimates under different assumptions about the association between failure and censoring. This analysis is especially useful when knowledge about such association is available through literature review or expert opinions. In a regression analysis setting, the consequences of falsely assuming independent censoring on parameter estimates are not clear. Neither the direction nor the magnitude of the potential bias can be easily predicted. We provide an approach to do sensitivity analysis for the widely used Cox proportional hazards models. The joint distribution of the failure and censoring times is assumed to be a function of their marginal distributions. This function is called a copula. Under this assumption, we propose an iteration algorithm to estimate the regression parameters and marginal survival functions. Simulation studies show that this algorithm works well. We apply the proposed sensitivity analysis approach to the data from an AIDS clinical trial in which 27% of the patients withdrew due to toxicity or at the request of the patient or investigator.

This paper examines some of the recent literature on the estimation of production functions. We focus on techniques suggested in two recent papers, Olley and Pakes (1996) and Levinsohn and Petrin (2003). While there are some solid and intuitive identification ideas in these papers, we argue that the techniques can suffer from functional dependence problems. We suggest an alternative approach that is based on the ideas in these papers, but does not suffer from the functional dependence problems and produces consistent estimates under alternative data generating processes for which the original procedures do not.

The paper deals with the estimation of a high dimensional covariance with a conditional sparsity structure and fast diverging eigenvalues. By assuming a sparse error covariance matrix in an approximate factor model, we allow for the presence of some cross-sectional correlation even after taking out common but unobservable factors. We introduce the principal orthogonal complement thresholding method 'POET' to explore such an approximate factor structure with sparsity. The POET-estimator includes the sample covariance matrix, the factor-based covariance matrix, the thresholding estimator and the adaptive thresholding estimator as specific examples. We provide mathematical insights when the factor analysis is approximately the same as the principal component analysis for high dimensional data. The rates of convergence of the sparse residual covariance matrix and the conditional sparse covariance matrix are studied under various norms. It is shown that the effect of estimating the unknown factors vanishes as the dimensionality increases. The uniform rates of convergence for the unobserved factors and their factor loadings are derived. The asymptotic results are also verified by extensive simulation studies. Finally, a real data application on portfolio allocation is presented.

We consider the problem of regularized maximum likelihood estimation for the structure and parameters of a high-dimensional, sparse directed acyclic graphical (DAG) model with Gaussian distribution, or equivalently, of a Gaussian structural equation model. We show that the ℓ 0 -penalized maximum likelihood estimator of a DAG has about the same number of edges as the minimal-edge I-MAP (a DAG with minimal number of edges representing the distribution), and that it converges in Frobenius norm. We allow the number of nodes p to be much larger than sample size n but assume a sparsity condition and that any representation of the true DAG has at least a fixed proportion of its nonzero edge weights above the noise level. Our results do not rely on the faithfulness assumption nor on the restrictive strong faithfulness condition which are required for methods based on conditional independence testing such as the PC-algorithm.

This article proposes a constrained ℓ 1 minimization method for estimating a sparse inverse covariance matrix based on a sample of n iid p-variate random variables. The resulting estimator is shown to have a number of desirable properties. In particular, the rate of convergence between the estimator and the true s-sparse precision matrix under the spectral norm is when the population distribution has either exponential-type tails or polynomial-type tails. We present convergence rates under the elementwise ℓ ∞ norm and Frobenius norm. In addition, we consider graphical model selection. The procedure is easily implemented by linear programming. Numerical performance of the estimator is investigated using both simulated and real data. In particular, the procedure is applied to analyze a breast cancer dataset and is found to perform favorably compared with existing methods.

We investigate the choice of the bandwidth for the regression discontinuity estimator. We focus on estimation by local linear regression, which was shown to have attractive properties (Porter, J. 2003, \"Estimation in the Regression Discontinuity Model\" (unpublished, Department of Economics, University of Wisconsin, Madison)). We derive the asymptotically optimal bandwidth under squared error loss. This optimal bandwidth depends on unknown functionals of the distribution of the data and we propose simple and consistent estimators for these functionals to obtain a fully data-driven bandwidth algorithm. We show that this bandwidth estimator is optimal according to the criterion of Li (1987, \"Asymptotic Optimality for C p , C L , Cross-validation and Generalized Cross-validation: Discrete Index Set\", Annals of Statistics, 15, 958–975), although it is not unique in the sense that alternative consistent estimators for the unknown functionals would lead to bandwidth estimators with the same optimality properties. We illustrate the proposed bandwidth, and the sensitivity to the choices made in our algorithm, by applying the methods to a data set previously analysed by Lee (2008, \"Randomized Experiments from Non-random Selection in U.S. House Elections\", Journal of Econometrics, 142, 675–697) as well as by conducting a small simulation study.

Controlling for unobserved heterogeneity (or \"common errors\"), such as industry-specific shocks, is a fundamental challenge in empirical research. This paper discusses the limitations of two approaches widely used in corporate finance and asset pricing research: demeaning the dependent variable with respect to the group (e.g., \"industry-adjusting\") and adding the mean of the group's dependent variable as a control. We show that these methods produce inconsistent estimates and can distort inference. In contrast, the fixed effects estimator is consistent and should be used instead. We also explain how to estimate the fixed effects model when traditional methods are computationally infeasible.

Instrumental variable (IV) methods are widely used to identify causal effects in models with endogenous explanatory variables. Often the instrument exclusion restriction that underlies the validity of the usual IV inference is suspect; that is, instruments are only plausibly exogenous. We present practical methods for performing inference while relaxing the exclusion restriction. We illustrate the approaches with empirical examples that examine the effect of 401(k) participation on asset accumulation, price elasticity of demand for margarine, and returns to schooling. We find that inference is informative even with a substantial relaxation of the exclusion restriction in two of the three cases.

This paper considers the maximum likelihood estimation of factor models of high dimension, where the number of variables (N) is comparable with or even greater than the number of observations (T). An inferential theory is developed. We establish not only consistency but also the rate of convergence and the limiting distributions. Five different sets of identification conditions are considered. We show that the distributions of the MLE estimators depend on the identification restrictions. Unlike the principal components approach, the maximum likelihood estimator explicitly allows heteroskedasticities, which are jointly estimated with other parameters. Efficiency of MLE relative to the principal components method is also considered.