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Autism, sensory & behavior : the way I see it
\"Dr. Temple Grandin draws on her own experience to deliver an essential resource for guiding and nurturing autistic children with sensory and behavior challenges. As always, she gets to the REAL issues of autism--the ones parents, teachers, and those on the spectrum face every day. Most autistic individuals deal with a variety of sensory differences, and in this book Dr. Grandin sheds light on the best ways for them to adapt and thrive. In these helpful pages, Dr. Grandin offers do's and don'ts, practical strategies, and try-it-now tips, all based on her insider perspective and extensive research\"--Page 4 of cover.
BOOK
Myocardial depression in sepsis: From pathogenesis to clinical manifestations and treatment
The cardiovascular system plays a key role in sepsis, and septic myocardial depression is a common finding associated with increased morbidity and mortality. Myocardial depression during sepsis is not clearly defined, but it can perhaps be best described as a global (systolic and diastolic) dysfunction of both the left and right sides of the heart. The pathogenesis of septic myocardial depression involves a complex mix of systemic (hemodynamic) factors and genetic, molecular, metabolic, and structural alterations. Pulmonary artery catheterization and modern echo-Doppler techniques are important diagnostic tools in this setting. There are no specific therapies for septic myocardial depression, and the cornerstone of management is control of the underlying infectious process (adequate antibiotic therapy, removal of the source) and hemodynamic stabilization (fluids, vasopressor and inotropic agents). In this review, we will summarize the pathogenesis, diagnosis, and treatment of myocardial depression in sepsis. Additional studies are needed in order to improve diagnosis and identify therapeutic targets in septic myocardial dysfunction.
Journal Article
Everyday games for Sensory Processing Disorder : 100 playful activities to empower children with sensory differences
\"...Occupational therapist Barbara Sher has over 45 years experience helping children with sensory processing disorder, autism and Asperger's learn and thrive. In this new solutions-based guide, she's collected 100 sensory-rich games that make working with your child a joy. If you're looking for new strategies to manage your child's sensory processing disorder, this book is a perfect companion to classics such as The Out-of-Sync Child and Raising a Sensory Smart Child. [This book] advocates play as the most effective approach for children with sensory processing disorder, and illustrates the many ways that play can lead to significant breakthroughs, including: 100 fun and simple games for parents to play with their kids ; An easy-to-grasp overview of sensory processing disorder ; Inventive ideas for engaging kids, using materials easily found around the house ; Inclusive games geared toward varying degrees of development, with modifications for older children.\"--Amazon.com.
Book
Impaired cardiac function is associated with mortality in patients with acute COVID-19 infection
BackgroundCOVID-19 infection may cause severe respiratory distress and is associated with increased morbidity and mortality. Impaired cardiac function and/or pre-existing cardiovascular disease may be associated with poor prognosis. In the present study, we report a comprehensive cardiovascular characterization in the first consecutive collective of patients that was admitted and treated at the University Hospital of Tübingen, Germany.Methods123 consecutive patients with COVID-19 were included. Routine blood sampling, transthoracic echocardiography and electrocardiography were performed at hospital admission.ResultsWe found that impaired left-ventricular and right-ventricular function as well as tricuspid regurgitation > grade 1 were significantly associated with higher mortality. Furthermore, elevated levels of myocardial distress markers (troponin-I and NT pro-BNP) were associated with poor prognosis in this patient collective.ConclusionImpaired cardiac function is associated with poor prognosis in COVID-19 positive patients. Consequently, treatment of these patients should include careful guideline-conform cardiovascular evaluation and treatment. Thus, formation of a competent Cardio-COVID-19 team may represent a major clinical measure to optimize therapy of cardiovascular patients during this pandemic.
Journal Article
The aging brain : functional adaptation across adulthood
\"Brain aging has long been seen as a process of deterioration and decline. Today, this view been challenged with research showing that not all cognitive processes decline with age, that some improve over the course of adulthood, and those that improve can often compensate for those that decline. Chapters in this multidisciplinary volume examine the neural mechanisms underlying changes in the aging brain, changes in learning and memory, risk and protective factors, and the assessment and prevention of cognitive decline\"--Provided by publisher.
Book
Biopsychosocial factors are associated with impaired sexual function in Mexican patients with rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic disease with worldwide representation that impacts every domain of a patient´s life, extending to sexual and reproductive domains. The study characterized sexual health (SH) and reproductive health (RH) in Mexican RA outpatients and identified factors associated with impaired sexual function (ISF).
From September 1, 2020-January 31, 2022, consecutive RA participants had semi-structured interviews focusing on their SH and RH biographies, and self-administered questionnaires were applied to assess patient-reported outcomes, including fatigue with the Functional Assessment of Chronic Illness Therapy-Fatigue scale (FACIT-F). ISF was defined based on published cut-offs of the International Index of Erectile Function (IIEF) in males and the Female Sexual Function Index (FSFI) in females (≥1 sexual intercourse in the last four weeks was required for index scoring). Multivariable logistic regression analysis was used to identify the factors associated with ISF.
There were 268 participants, and 246 (91.8%) were females. Participants had 13 years of disease duration. Among females, 151 (61.4%) had FSFI applied, and the satisfaction domain was impaired in 111 (73.5%). Among males (N = 22), 17 (77.3%) had IIEF applied, and erectile dysfunction was present in 5 (29.4%). Almost half of the participants denied using a family planning method, were in their 50s, and receiving teratogenic drugs; 89.7% of the participants had children. ISF was detected in 94 (62.3%) females and 3 (17.6%) males. Male sex (aOR: 0.07, 95%CI: 0.01-0.36, p = 0.001), FACIT-F score (aOR: 0.96, 95%CI: 0.92-1.00, p = 0.03), and cohabitation with the couple (aOR: 0.32, 95%CI: 0.11-0.96, p = 0.04) were associated with ISF.
We observed a disproportionate burden of ISF among women with RA compared to male participants. Male sex, lesser fatigue, and cohabitation with the couple were protective against ISF. Regardless of the prevalent use of teratogenic medications, contraceptive use was suboptimal among the participants.
Journal Article
Building social skills for autism, sensory processing disorders and learning disabilities : over 105 strategies, activities and sensory tools for children and adolescents
\"This new framework for developing a dynamic social skills program using the sensory system is a way to explore why kids react that way they do socially. With this framework in mind, professionals can build on children's self-awareness and social acumen\"--Page 4 of cover.
Book
Clinical Spectrum, Frequency, and Significance of Myocardial Dysfunction in Severe Sepsis and Septic Shock
To determine the frequency and spectrum of myocardial dysfunction in patients with severe sepsis and septic shock using transthoracic echocardiography and to evaluate the impact of the myocardial dysfunction types on mortality.
A prospective study of 106 patients with severe sepsis or septic shock was conducted from August 1, 2007, to January 31, 2009. All patients underwent transthoracic echocardiography within 24 hours of admission to the intensive care unit. Myocardial dysfunction was classified as left ventricular (LV) diastolic, LV systolic, and right ventricular (RV) dysfunction. Frequency of myocardial dysfunction was calculated, and demographic, hemodynamic, and physiologic variables and mortality were compared between the myocardial dysfunction types and patients without cardiac dysfunction.
The frequency of myocardial dysfunction in patients with severe sepsis or septic shock was 64% (n=68). Left ventricular diastolic dysfunction was present in 39 patients (37%), LV systolic dysfunction in 29 (27%), and RV dysfunction in 33 (31%). There was significant overlap. The 30-day and 1-year mortality rates were 36% and 57%, respectively. There was no difference in mortality between patients with normal myocardial function and those with left, right, or any ventricular dysfunction.
Myocardial dysfunction is frequent in patients with severe sepsis or septic shock and has a wide spectrum including LV diastolic, LV systolic, and RV dysfunction types. Although evaluation for the presence and type of myocardial dysfunction is important for tailoring specific therapy, its presence in patients with severe sepsis and septic shock was not associated with increased 30-day or 1-year mortality.
Journal Article
Too much! : an overwhelming day
\"Sometimes everything is too much! Too loud, too bright, and all too overwhelming. Writing from her own experience with sensory processing disorder, Jolene Gutiérrez's compassionate picture book explores the struggles of a sensorily sensitive child and how they settle themselves. Joined by Angel Chang's beautiful illustrations, young readers will learn that it's OK if some days are too much\"-- Provided by publisher.
Book
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.
Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.
Journal Article