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Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
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Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
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Journal Article
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
2021
Overview
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.
Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 59/57
/ 59/78
/ 631/378
/ Adult
/ Age
/ Aged
/ Aging
/ Alzheimer Disease - diagnostic imaging
/ Alzheimer Disease - genetics
/ Alzheimer Disease - metabolism
/ Amyloid beta-Peptides - metabolism
/ Brain
/ Cognitive Dysfunction - diagnostic imaging
/ Cognitive Dysfunction - genetics
/ Cognitive Dysfunction - metabolism
/ Female
/ Functional magnetic resonance imaging
/ Genetic Predisposition to Disease - genetics
/ Humanities and Social Sciences
/ Humans
/ Magnetic Resonance Imaging - methods
/ Male
/ Mutation
/ Positron-Emission Tomography - methods
/ Science
