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Laboratory Guide to the Methods in Biochemical Genetics
This manual deals specifically with laboratory approaches to diagnosing inborn errors of metabolism. The key feature is that each chapter is sufficiently detailed so that any individual can adopt the described method into their own respective laboratory.
eBook
Using the fundamentals of the theory of measurement errors in performing geodesic measurement and calculation works
In this article, the tasks of the theory of measurement errors during geodetic measurement and calculation practices, equal and unequal measurements and measurement errors, i.e. deviations from the actual values of the measured quantity as a result of measurement issues aimed at elucidating the work and their classifications are covered. Also, the criteria of measurement accuracy, expressions for their determination, as well as the procedure for processing one quantity measured with equal accuracy and a sample example of its implementation are given.
Journal Article
Boy, were we wrong about dinosaurs!
Examines what is known about dinosaur bones, behavior, and other characteristics and how different the facts often are from what scientists, from ancient China to the recent past, believed to be true.
Book
Two Decades Since To Err Is Human : An Assessment Of Progress And Emerging Priorities In Patient Safety
The Institute of Medicine's To Err Is Human, published in 1999, represented a watershed moment for the US health care system. The report dramatically raised the profile of patient safety and stimulated dedicated research funding to this essential aspect of patient care. Highly effective interventions have since been developed and adopted for hospital-acquired infections and medication safety, although the impact of these interventions varies because of their inconsistent implementation and practice. Progress in addressing other hospital-acquired adverse events has been variable. In the past two decades additional areas of safety risk have been identified and targeted for intervention, such as outpatient care, diagnostic errors, and the use of health information technology. In sum, the frequency of preventable harm remains high, and new scientific and policy approaches to address both prior and emerging risk areas are imperative. With the increasing availability of electronic data, investments must now be made in developing and testing methods to routinely and continuously measure the frequency and types of patient harm and even predict risk of harm for specific patients. This progress could lead us from a Bronze Age of rudimentary tool development to a Golden Era of vast improvement in patient safety.
Journal Article
Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency
In this study, approximately half the patients with red-cell pyruvate kinase deficiency who were treated with mitapivat had an improvement in their hemoglobin level and decreased hemolysis that was sustained for nearly 3 years. Patients who had missense mutations that allowed for synthesis of a hypofunctioning enzyme were most likely to have a response.
Journal Article
Getting it right in science and medicine : can science progress through errors? Fallacies and facts
This book advocates the importance and value of errors for the progress of scientific research. Hans Kricheldorf explains that most of the great scientific achievements are based on an iterative process (an 'innate self-healing mechanism'): errors are committed, being checked over and over again, through which finally new findings and knowledge can arise. New ideas are often first confronted with refusal. This is so not only in real life, but also in scientific and medical research. The author outlines in this book how great ideas had to ripen over time before winning recognition and being accepted. The book showcases in an entertaining way, but without schadenfreude, that even some of the most famous discoverers may appear in completely different light, when regarding errors they have committed in their work. This book is divided into two parts. The first part creates a fundament for the discussion and understanding by introducing important concepts, terms and definitions, such as (natural) sciences and scientific research, laws of nature, paradigm shift, and progress (in science). It compares natural sciences with other scientific disciplines, such as historical research or sociology, and examines the question if scientific research can generate knowledge of permanent validity. The second part contains a collection of famous fallacies and errors from medicine, biology, chemistry, physics and geology, and how they were corrected. Readers will be astonished and intrigued what meanders had to be explored in some cases before scientists realized facts, which are today's standard and state-of-the-art of science and technology. This is an entertaining and amusing, but also highly informative book not only for scientists and specialists, but for everybody interested in science, research, their progress, and their history. -- Provided by publisher.
Book
Lower complexity error location detection block of adjacent error correcting decoder for SRAMs
Multiple cell upsets (MCUs) caused by radiation is an important issue related to the reliability of embedded static random access memories (SRAMs). Multiple random and adjacent error correcting codes have been extensively employed for several years to protect stored data in SRAMs against MCUs. A compact and fast error correcting codec is desirable in most of these applications. In this study, simplified expressions for error location detection (ELD) block for single error correction-double error detection-double adjacent error correction (SEC-DED-DAEC) and single error correction-double error detection-triple adjacent error correction (SEC-DED-TAEC) decoders have been obtained by employing Karnaugh map. The conventional SEC-DED-DAEC and SEC-DED-TAEC decoders have been designed and implemented in both field-programmable gate array and ASIC platforms by considering these simplified ELD expressions. In FPGA platform, the proposed design for SEC-DED-DAEC and SEC-DED-TAEC decoders require 1.37–28.40% improvement in area and maximum 14.74% improvement in delay compared to existing designs. Whereas ASIC-based designs provide 2.20–26.81% reduction in area and 0.30–28.96% reduction in delay compared to existing related works. So the proposed design can be considered as an efficient alternative of traditional adjacent error correcting decoders in resource constraint applications.
Journal Article