Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

by Kuo, Kevin H.M , van Beers, Eduard J , Barbier, Ann J , Hua, Lei , Layton, D. Mark , Yaish, Hassan , Jouvin, Marie-Hélène , Morton, D. Holmes , Bodie, Susan , Glader, Bertil , Rose, Christian , Hawkins, Peter , Sheth, Sujit , Ravindranath, Yaddanapudi , Grace, Rachael F , Galactéros, Frédéric , Kwiatkowski, Janet L , Bowden, Chris , Silver, Bruce , Kung, Charles , Barcellini, Wilma

in Administration, Oral / Adolescent / Adult / Allosteric properties / Anemia / Anemia, Hemolytic, Congenital Nonspherocytic - blood / Anemia, Hemolytic, Congenital Nonspherocytic - drug therapy / Anemia, Hemolytic, Congenital Nonspherocytic - genetics / Catechols / Drug Administration Schedule / Female / Follow-Up Studies / Glucose / Headache / Headache - chemically induced / Hemoglobin / Hemoglobins - metabolism / Hemolytic anemia / Humans / Investigations / Kinases / Male / Mutation / Pharyngitis / Piperazines - administration & dosage / Piperazines - adverse effects / Pyruvate kinase / Pyruvate Kinase - blood / Pyruvate Kinase - deficiency / Pyruvate Kinase - genetics / Pyruvate Metabolism, Inborn Errors - blood / Pyruvate Metabolism, Inborn Errors - drug therapy / Pyruvate Metabolism, Inborn Errors - genetics / Pyruvic acid / Quinolines - administration & dosage / Quinolines - adverse effects / Sleep disorders / Sleep Initiation and Maintenance Disorders - chemically induced / Tyrphostins / Young Adult

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

2019

Confirm

Do you wish to request the book?

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency

Kuo, Kevin H.M,

van Beers, Eduard J,

Barbier, Ann J,

Hua, Lei,

Layton, D. Mark,

Yaish, Hassan,

Jouvin, Marie-Hélène,

Morton, D. Holmes,

Bodie, Susan,

Glader, Bertil,

Rose, Christian,

Hawkins, Peter,

Sheth, Sujit,

Ravindranath, Yaddanapudi,

Grace, Rachael F,

Galactéros, Frédéric,

Kwiatkowski, Janet L,

Bowden, Chris,

Silver, Bruce,

Kung, Charles,

Barcellini, Wilma

2019

Overview

In this study, approximately half the patients with red-cell pyruvate kinase deficiency who were treated with mitapivat had an improvement in their hemoglobin level and decreased hemolysis that was sustained for nearly 3 years. Patients who had missense mutations that allowed for synthesis of a hypofunctioning enzyme were most likely to have a response.

Share this book

Add to My Shelf

Publisher

Massachusetts Medical Society

Subject

Administration, Oral

/ Adolescent

/ Adult

/ Allosteric properties

/ Anemia

/ Anemia, Hemolytic, Congenital Nonspherocytic - blood

/ Anemia, Hemolytic, Congenital Nonspherocytic - drug therapy