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Background Liver uptake in [ 68 Ga]Ga-PSMA-11 PET is used as an internal reference in addition to clinical parameters to select patients for [ 177 Lu]Lu-PSMA-617 radioligand therapy (RLT). Due to increased demand, [ 68 Ga]Ga-PSMA-11 was replaced by [ 18 F]F-PSMA-1007, a more lipophilic tracer with different biodistribution and splenic uptake was suggested as a new internal reference. We compared the intra-patient tracer distribution between [ 68 Ga]Ga-PSMA-11 and [ 18 F]F-PSMA-1007. Methods Fifty patients who underwent PET examinations in two centers with both [ 18 F]F-PSMA-1007 and [ 68 Ga]Ga-PSMA-11 within one year were included. Mean standardized uptake values (SUV mean ) were obtained for liver, spleen, salivary glands, blood pool, and bone. Primary tumor, local recurrence, lymph node, bone or visceral metastasis were also assessed for intra- and inter-individual comparison. Results Liver SUV mean was significantly higher with [ 18 F]F-PSMA-1007 (11.7 ± 3.9) compared to [ 68 Ga]Ga-PSMA-11 (5.4 ± 1.7, p  < .05) as well as splenic SUV mean (11.2 ± 3.5 vs.8.1 ± 3.5, p  < .05). The blood pool was comparable between the two scans. Malignant lesions did not show higher SUV mean on [ 18 F]F-PSMA-1007. Intra-individual comparison of liver uptake between the two scans showed a linear association for liver uptake with SUV mean [ 68 Ga]Ga-PSMA-11 = 0.33 x SUV mean [ 18 F]F-PSMA-1007 + 1.52 ( r  = .78, p  < .001). Conclusion Comparing biodistribution of [ 68 Ga]Ga and [ 18 F]F tracers, liver uptake on [ 68 Ga]Ga-PSMA-11 PET is the most robust internal reference value. Liver uptake of [ 18 F]F-PSMA-1007 was significantly higher, but so was the splenic uptake. The strong intra-individual association of hepatic accumulation between the two scans may allow using of a conversion factor for [ 18 F]F-PSMA-1007 as a basis for RLT selection.