Asset Details
Do you wish to reserve the book?
Evaluating the biodistribution for 68GaGa-PSMA-11 and 18FF-PSMA-1007 PET/CT with an inter- and intrapatient based analysis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Evaluating the biodistribution for 68GaGa-PSMA-11 and 18FF-PSMA-1007 PET/CT with an inter- and intrapatient based analysis
Do you wish to request the book?
Evaluating the biodistribution for 68GaGa-PSMA-11 and 18FF-PSMA-1007 PET/CT with an inter- and intrapatient based analysis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Evaluating the biodistribution for 68GaGa-PSMA-11 and 18FF-PSMA-1007 PET/CT with an inter- and intrapatient based analysis
2024
Overview
Background
Liver uptake in [
68
Ga]Ga-PSMA-11 PET is used as an internal reference in addition to clinical parameters to select patients for [
177
Lu]Lu-PSMA-617 radioligand therapy (RLT). Due to increased demand, [
68
Ga]Ga-PSMA-11 was replaced by [
18
F]F-PSMA-1007, a more lipophilic tracer with different biodistribution and splenic uptake was suggested as a new internal reference. We compared the intra-patient tracer distribution between [
68
Ga]Ga-PSMA-11 and [
18
F]F-PSMA-1007.
Methods
Fifty patients who underwent PET examinations in two centers with both [
18
F]F-PSMA-1007 and [
68
Ga]Ga-PSMA-11 within one year were included. Mean standardized uptake values (SUV
mean
) were obtained for liver, spleen, salivary glands, blood pool, and bone. Primary tumor, local recurrence, lymph node, bone or visceral metastasis were also assessed for intra- and inter-individual comparison.
Results
Liver SUV
mean
was significantly higher with [
18
F]F-PSMA-1007 (11.7 ± 3.9) compared to [
68
Ga]Ga-PSMA-11 (5.4 ± 1.7,
p
< .05) as well as splenic SUV
mean
(11.2 ± 3.5 vs.8.1 ± 3.5,
p
< .05). The blood pool was comparable between the two scans. Malignant lesions did not show higher SUV
mean
on [
18
F]F-PSMA-1007. Intra-individual comparison of liver uptake between the two scans showed a linear association for liver uptake with SUV
mean
[
68
Ga]Ga-PSMA-11 = 0.33 x SUV
mean
[
18
F]F-PSMA-1007 + 1.52 (
r
= .78,
p
< .001).
Conclusion
Comparing biodistribution of [
68
Ga]Ga and [
18
F]F tracers, liver uptake on [
68
Ga]Ga-PSMA-11 PET is the most robust internal reference value. Liver uptake of [
18
F]F-PSMA-1007 was significantly higher, but so was the splenic uptake. The strong intra-individual association of hepatic accumulation between the two scans may allow using of a conversion factor for [
18
F]F-PSMA-1007 as a basis for RLT selection.
