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Group IIA secreted phospholipase A 2 (group IIA sPLA 2 ) is known to display potent Gram-positive bactericidal activity in vitro and in vivo. We have analyzed the bactericidal activity of the full set of native stingray and dromedary groups V, IIA, and IB sPLA 2 s on several Gram-positive and Gram-negative strains. The rank order potency among both marine and mammal sPLA 2 s against Gram-positive bacteria is group IIA > V > IB, whereas Gram-negative bacteria exhibited a much higher resistance. There is a synergic action of the sPLA 2 with lysozyme when added to the bacteria culture prior to sPLA 2 .The bactericidal efficiency of groups V and IIA sPLA 2 s was shown to be dependent upon the presence of calcium ions and to a less extent Mg 2+ ions and then a correlation could be made to its hydrolytic activity of membrane phospholipids. Importantly, we showed that stingray and dromedary groups V, IIA, and IB sPLA 2 s present no cytotoxicity after their incubation with MDA-MB-231cells. stingray groups V and IIA sPLA 2 s, like mammal ones, may be considered as future therapeutic agents against bacterial infections.