Asset Details
Do you wish to reserve the book?
Anti-Bactericidal Properties of Stingray Dasyatis pastinaca Groups V, IIA, and IB Phospholipases A2: A Comparative Study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Anti-Bactericidal Properties of Stingray Dasyatis pastinaca Groups V, IIA, and IB Phospholipases A2: A Comparative Study
Do you wish to request the book?
Anti-Bactericidal Properties of Stingray Dasyatis pastinaca Groups V, IIA, and IB Phospholipases A2: A Comparative Study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Anti-Bactericidal Properties of Stingray Dasyatis pastinaca Groups V, IIA, and IB Phospholipases A2: A Comparative Study
2014
Overview
Group IIA secreted phospholipase A
2
(group IIA sPLA
2
) is known to display potent Gram-positive bactericidal activity in vitro and in vivo. We have analyzed the bactericidal activity of the full set of native stingray and dromedary groups V, IIA, and IB sPLA
2
s on several Gram-positive and Gram-negative strains. The rank order potency among both marine and mammal sPLA
2
s against Gram-positive bacteria is group IIA > V > IB, whereas Gram-negative bacteria exhibited a much higher resistance. There is a synergic action of the sPLA
2
with lysozyme when added to the bacteria culture prior to sPLA
2
.The bactericidal efficiency of groups V and IIA sPLA
2
s was shown to be dependent upon the presence of calcium ions and to a less extent Mg
2+
ions and then a correlation could be made to its hydrolytic activity of membrane phospholipids. Importantly, we showed that stingray and dromedary groups V, IIA, and IB sPLA
2
s present no cytotoxicity after their incubation with MDA-MB-231cells. stingray groups V and IIA sPLA
2
s, like mammal ones, may be considered as future therapeutic agents against bacterial infections.
Publisher
Springer US,Springer
Subject
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Biological and medical sciences
/ calcium
/ Chemistry and Materials Science
/ Fish Proteins - pharmacology
/ Fundamental and applied biological sciences. Psychology
/ Gram-Positive Bacteria - growth & development
/ Group IB Phospholipases A2 - chemistry
/ Group IB Phospholipases A2 - pharmacology
/ Group II Phospholipases A2 - chemistry
/ Group II Phospholipases A2 - pharmacology
/ Group V Phospholipases A2 - chemistry
/ Group V Phospholipases A2 - pharmacology
/ ions
/ lysozyme
