Explore the vast range of titles available.

Climate change is likely to increase the frequency of drought and more extreme precipitation events. The objectives of this study were i) to assess the impact of extended drought followed by heavy precipitation events on yield and soil organic carbon (SOC) under historical and future climate, and ii) to evaluate the effectiveness of climate adaptation strategies (no-tillage and new cultivars) in mitigating impacts of increased frequencies of extreme events and warming. We used the validated SALUS crop model to simulate long-term maize and wheat yield and SOC changes of maize-soybean-wheat rotation cropping systems in the northern Midwest USA under conventional tillage and no-till for three climate change scenarios (one historical and two projected climates under the Representative Concentration Path (RCP) 4.5 and RCP6) and two precipitation changes (extreme precipitation occurring early or late season). Extended drought events caused additional yield reduction when they occurred later in the season (10-22% for maize and 5-13% for wheat) rather than in early season (5-17% for maize and 2-18% for wheat). We found maize grain yield declined under the projected climates, whereas wheat grain yield increased. No-tillage is able to reduce yield loss compared to conventional tillage and increased SOC levels (1.4-2.0 t/ha under the three climates), but could not reverse the adverse impact of climate change, unless early and new improved maize cultivars are introduced to increase yield and SOC under climate change. This study demonstrated the need to consider extreme weather events, particularly drought and extreme precipitation events, in climate impact assessment on crop yield and adaptation through no-tillage and new genetics reduces yield losses.

Nanophthalmos is a rare, potentially devastating eye condition characterized by small eyes with relatively normal anatomy, a high hyperopic refractive error, and frequent association with angle closure glaucoma and vision loss. The condition constitutes the extreme of hyperopia or farsightedness, a common refractive error that is associated with strabismus and amblyopia in children. NNO1 was the first mapped nanophthalmos locus. We used combined pooled exome sequencing and strong linkage data in the large family used to map this locus to identify a canonical splice site alteration upstream of the last exon of the gene encoding myelin regulatory factor (MYRF c.3376-1G>A), a membrane bound transcription factor that undergoes autoproteolytic cleavage for nuclear localization. This variant produced a stable RNA transcript, leading to a frameshift mutation p.Gly1126Valfs*31 in the C-terminus of the protein. In addition, we identified an early truncating MYRF frameshift mutation, c.769dupC (p.S264QfsX74), in a patient with extreme axial hyperopia and syndromic features. Myrf conditional knockout mice (CKO) developed depigmentation of the retinal pigment epithelium (RPE) and retinal degeneration supporting a role of this gene in retinal and RPE development. Furthermore, we demonstrated the reduced expression of Tmem98, another known nanophthalmos gene, in Myrf CKO mice, and the physical interaction of MYRF with TMEM98. Our study establishes MYRF as a nanophthalmos gene and uncovers a new pathway for eye growth and development.

The main goals of the Institute of Medicine's 1988 report The Future of Public Health^ are laudable and still necessary today. This report recognized that the mission of public health is \"fulfilling society's interest in assuring conditions in which people can be healthy.\"1 (p7) To achieve this, all levels of the governmental public health fieldfederal, state, local, and tribal-must be engaged in addressing the defined core functions. One major concern, as the COVID-19 pandemic has demonstrated, is that 36years later, although we have made improvements, the overarching goals of the report remain aspirational. The COVID-19 pandemic brought into sharp focus the need for a cross-sector, multidisciplinary approach, and the American Public Health Association responded by organizing the Alliance for Disease Prevention and Response.2 The Alliance is a collaborative initiative focusing on advancing a strong public health system for everyone and includes 80 cross-sectoral organizations. The Alliance has received support from the CDC Foundation, Kaiser Permanente, the Rockefeller Foundation, the Skoll Foundation, and the W.K. Kellogg Foundation. The Alliance's goal is to accelerate building a robust and resilient public health system that advances health and well-being for all. After extensive study and input from the public health community and crosssectoral and community-based partners, we believe a key next step is to launch a large cross-sectoral movement, including an action arm, the Campaign for the Public's Health, to expand active engagement and collaboration and champion advances in public health and equity. This will involve catalyzing community-level partnership, communicating a shared vision, and jointly advocating supportive policy and system building. Linchpins of these efforts are collaboration and alignment, avoiding redundancy, and identifying organizations ready to lead, champion, support, and amplify the work of others to reach shared goals.

Background A growing body of evidence links socioeconomic status (SES) to children's brain structure. Few studies, however, have specifically investigated relations of SES to white matter structure. Further, although several studies have demonstrated that family SES is related to development of brain areas that support executive functions (EF), less is known about the role that white matter structure plays in the relation of SES to EF. One possibility is that white matter differences may partially explain SES disparities in EF (i.e., a mediating relationship). Alternatively, SES may differentially shape brain‐behavior relations such that the relation of white matter structure to EF may differ as a function of SES (i.e., a moderating relationship). Method In a diverse sample of 1082 children and adolescents aged 3–21 years, we examined socioeconomic disparities in white matter macrostructure and microstructure. We further investigated relations between family SES, children's white matter volume and integrity in tracts supporting EF, and performance on EF tasks. Results Socioeconomic status was associated with fractional anisotropy (FA) and volume in multiple white matter tracts. Additionally, family income moderated the relation between white matter structure and cognitive flexibility. Specifically, across multiple tracts of interest, lower FA or lower volume was associated with reduced cognitive flexibility among children from lower income families. In contrast, children from higher income families showed preserved cognitive flexibility in the face of low white matter FA or volume. SES factors did not mediate or moderate links between white matter and either working memory or inhibitory control. Conclusions This work adds to a growing body of literature suggesting that the socioeconomic contexts in which children develop not only shape cognitive functioning and its underlying neurobiology, but may also shape the relations between brain and behavior. In a diverse sample of 1082 children and adolescents aged 3–21 years, we examine socioeconomic disparities in white matter macrostructure and microstructure. We further investigate relations between family SES, children's white matter volume and integrity in tracts supporting EF, and performance on EF tasks.

To investigate the clinical features and surgical outcomes of rhegmatogenous retinal detachment (RRD) associated with giant retinal tears (GRTs) at a tertiary referral center. A retrospective, non-consecutive interventional case series of GRT-associated RRDs that underwent primary surgical repair at the University of Michigan W.K. Kellogg Eye Center between January 1, 2011 and July 1, 2020. Clinical characteristics and preoperative, perioperative, and postoperative data were collected. Forty-eight eyes of 47 patients with GRT-associated RRDs met inclusion criteria, including those that were children (under 12 years, N=4, 8.3%), associated with a history of trauma (N=20, 41.7%) or with grade C proliferative vitreoretinopathy (PVR-C) (N=7, 14.6%) at baseline. Median age was 46 years (interquartile range (IQR): 29 years, range: 4 to 72 years), median follow-up was 28 months (IQR: 43 months, range: 3-124 months), and 83.3% (N=40) of subjects were male. Primary surgical repair for GRT-associated RRDs included pars plana vitrectomy (PPV) (N=40, 83.3%), scleral buckle (SB) (N=1, 2.1%), or combined PPV/SB (N=7, 14.6%). Surgical approach commonly involved the use of perfluorocarbon liquid (N=43, 90%) and gas tamponade (N=39, 81%). Single surgery anatomic success (SSAS) was 75% (95% CI: 60%, 85%) at 3 months and 65% (95 CI: 47%, 78%) at 2 years. Final anatomic success was achieved in all 48 eyes (100%). Median visual acuity improved from 20/250 preoperatively to 20/60 at final follow-up, with 44% (N=20) of eyes achieving postoperative visual acuity of 20/40 or better. In this series from a tertiary referral center, both complex and non-complex GRT-associated RRDs were most commonly managed with PPV alone, perfluorocarbon liquid, and gas tamponade with favorable final anatomic and visual outcomes comparable to other modern GRT series.

In this study, we used data drawn from a 2021 online survey to assess urban Texas residents' perceptions of rural people and places. We also evaluated how respondents' views of rurality vary depending upon their direct personal experiences in rural Texas, their participation in selected rural Texas-focused activities, and their sociodemographic characteristics. Descriptive statistics revealed that urban Texans tend to agree with positive depictions of rurality and disagree with negative images. Multiple regression analysis showed that direct personal experiences in rural Texas, participation in rural Texas-focused activities, and certain sociodemographic characteristics were associated with pro-rural perceptions. These findings are compared with the results of previous studies. Suggestions for future research are provided.

[...]ongoing surveillance for the development of UTIs and traumatic insertions after using the touch-free hydrophilic catheter is recommended to assess its impact over a longer period with a larger number of patients. Because of the consequence to patient's health and well-being, the Centers for Medicare & Medicaid Services decided not to reimburse hospitals for these nosocomial CAUTI infections (Agency for Healthcare Research and Quality [AHRQ], 2015). [...]infection and inflammation that result in edema of the bladder or urethra can lead to retention (Serlin et al, 2018). [...]the methodologies define data collection techniques that can be qualitative, quantitative, or both.

The authors present a unique case of bilateral isolated choroidal melanocytosis in an annular pattern that, to our knowledge, has not previously been described. A 44-year-old asymptomatic American Indian woman presented with bilateral choroidal hyperpigmentation in an annular pattern for 12 clock hours around the peripheral retina. No other uveal, scleral, or cutaneous hyperpigmentation was observed. Optical coherence tomography did not demonstrate choroidal thickening or subretinal fluid. The diagnosis of bilateral isolated choroidal melanocytosis was made. Long-term follow-up of this patient and other cases described in the literature is necessary to determine the malignant potential of these lesions. [ Ophthalmic Surg Lasers Imaging Retina . 2019;50:e74–e76.]

BackgroundAdequate mentoring and support of community service nurses (CSNs) in transitioning from the learning environment to the public health setting is pivotal. Despite this notion, the mentoring of CSNs is inconsistently implemented. It was therefore imperative that the researchers developed the guidelines that can be used by managers to mentor the CSNs.AimThis article shares nine guidelines to ensure adequate mentoring of CSNs in public health settings.SettingThe study was conducted in public health settings designated for placement of CSNs, in South Africa.MethodsThis study followed a convergent parallel mixed-methods design whereby qualitative data were obtained from purposefully selected CSNs and nurse managers. Quantitative data were obtained from 224 CSNs and 174 nurse managers, with the use of mentoring questionnaires. Semi-structured interviews were used on focus groups of nurse managers (n = 27) and CSNs (n = 28). Quantitative data were analysed with Statistical Package for Social Science software version 23, ATLAS.ti 7 software was used to analyse qualitative data.ResultsThe merged results evidenced that CSNs were not adequately mentored. The public health setting was not conducive to mentoring CSNs. Mentoring activities were not well structured. Monitoring and evaluation of mentoring of CSNs were not properly done. Evidence from merged results and literature were applied to develop mentoring guidelines for operationalising a mentoring programme for CSNs.ConclusionThe guidelines were: (1) creation of a positive mentoring environment, (2) enhancement of collaboration between stakeholders, (3) attributes of CSNs and nurse managers in the mentoring relationship, (4) enhance orientation for nurse managers and CSNs, (5) facilitation of mentor–mentee matching process, (6) conducting mentoring meetings, (7) capacity development for CSNs and nurse managers, (8) monitoring and evaluation of mentoring process, and (9) reflections and feedback.ContributionThis was the first CSNs’ guidelines to be developed in the public health setting. These guidelines could facilitate adequate mentoring of CSNs.

How well do self‐reported levels of community and organizational participation align with recorded acts of community and organizational participation? This study explores this question among participants in social action community organizing initiatives by comparing responses on a community participation scale designed to retrospectively assess community participation (T1, n = 482; T2, n = 220) with individual participants' attendance records in various social action organizing activities over two 1‐year periods. By testing the self‐reported measure's overall and item‐by‐item association with documented participation in various types of organizing activities, we find that the self‐report measure is positively, but weakly correlated with actual participation levels in community organizing activities. Moreover, associations between self‐report and recorded acts of participation differ by types of activity. Examining this unique source of data raises important questions about how community participation is conceptualized and measured in our field. Implications are explored for theory and measurement of participation in community and organizational contexts.