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"Nanofibers"
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Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation
Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack of knowledge about natural drug gels limits there current application. Here, we report on rhein, a herbal natural product, which is directly self-assembled into hydrogels through noncovalent interactions. This hydrogel shows excellent stability, sustained release and reversible stimuli-responses. The hydrogel consists of a three-dimensional nanofiber network that prevents premature degradation. Moreover, it easily enters cells and binds to toll-like receptor 4. This enables rhein hydrogels to significantly dephosphorylate IκBα, inhibiting the nuclear translocation of p65 at the NFκB signalling pathway in lipopolysaccharide-induced BV2 microglia. Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. This study highlights a direct self-assembly hydrogel from natural small molecule as a promising neuroinflammatory therapy.
There is interest in the development of drug-based hydrogels for responsive sustained drug release. Here, the authors report on the self-assembly of natural small molecule, rhein, into hydrogels and the application of the hydrogels as stable controlled release agents for neuro-inflammatory therapy
Journal Article
Recent Advances in Electrospun Nanofiber Interfaces for Biosensing Devices
Electrospinning has emerged as a very powerful method combining efficiency, versatility and low cost to elaborate scalable ordered and complex nanofibrous assemblies from a rich variety of polymers. Electrospun nanofibers have demonstrated high potential for a wide spectrum of applications, including drug delivery, tissue engineering, energy conversion and storage, or physical and chemical sensors. The number of works related to biosensing devices integrating electrospun nanofibers has also increased substantially over the last decade. This review provides an overview of the current research activities and new trends in the field. Retaining the bioreceptor functionality is one of the main challenges associated with the production of nanofiber-based biosensing interfaces. The bioreceptors can be immobilized using various strategies, depending on the physical and chemical characteristics of both bioreceptors and nanofiber scaffolds, and on their interfacial interactions. The production of nanobiocomposites constituted by carbon, metal oxide or polymer electrospun nanofibers integrating bioreceptors and conductive nanomaterials (e.g., carbon nanotubes, metal nanoparticles) has been one of the major trends in the last few years. The use of electrospun nanofibers in ELISA-type bioassays, lab-on-a-chip and paper-based point-of-care devices is also highly promising. After a short and general description of electrospinning process, the different strategies to produce electrospun nanofiber biosensing interfaces are discussed.
Journal Article
Piezoelectric Properties of Electrospun Polymer Nanofibers and Related Energy Harvesting Applications
Electrospinning (ES) methods that can produce piezoelectricity in polymer nanofibers have attracted tremendous research attention. These electrospun polymer nanofibers can be employed for sensors, energy harvesting, tissue engineering, and filtration applications. This paper reviews the performance of a variety of electrospun piezoelectric polymer nanofibers produced by different ES methods, including near‐field electrospinning and conventional far‐field electrospinning methods. Herein, it is described how the ES method can affect the piezoelectric properties of various polymer nanofibers, including poly(vinylidene difluorine), poly(vinylidene fluoride‐trifluoroethylene), nylon 11, poly(l‐lactic acid), and poly(α‐benzyl‐l‐glutamate). Due to the varied matrix structures of piezoelectric polymer nanofibers, the ES method may conduct variable effects on the piezoelectric properties of polymer nanofibers. After characterizations by X‐ray diffraction, Fourier transform infrared spectrum, dielectric spectra, and piezoelectric coefficient measurements, it is found that the piezoelectric properties of the polymer nanofibers can be significantly affected by the ES parameters. Most of previous review articles focus on the output performance of electrospun polymer nanofibers. A detailed description of how different ES methods affect the piezoelectricity of polymer nanofibers is still lacking. In this review paper, the basic principle behind ES methods and the way in which different ES methods affect the properties of polymer nanofibers are examined. This paper reviews the piezoelectric properties of electrospun polymer nanofibers produced by different electrospinning (ES) methods, including near‐field electrospinning and conventional far‐field electrospinning methods. The polymers include poly(vinylidene difluorine), nylon 11, poly(l‐lactic acid), and poly(α‐benzyl‐l‐glutamate). The aim of the review is to find the basic principle behind ES methods and how different ES methods affect the properties of polymer nanofibers.
Journal Article
Manganese cobalt-MOF@carbon nanofiber-based non-enzymatic histamine sensor for the determination of food freshness
Early detection of histamine in foodstuffs/beverages could be useful in preventing various diseases. In this work, we have prepared a free-standing hybrid mat based on manganese cobalt (2-methylimodazole)–metal organic frameworks (Mn-Co(2-MeIm)MOF) and carbon nanofibers (CNFs) and explored as a non-enzymatic electrochemical sensor for determining the freshness of fish and bananas based on histamine estimation. As-developed hybrid mat possesses high porosity with a large specific surface area and excellent hydrophilicity those allow easy access of analyte molecules to the redox-active metal sites of MOF. Furthermore, the multiple functional groups of the MOF matrix can act as active adsorption sites for catalysis. The Mn-Co(2-MeIm)MOF@CNF mat-modified GC electrode demonstrated excellent electrocatalytic activities toward the oxidation of histamine under acidic conditions (pH = 5.0) with a faster electron transfer kinetics and superior fouling resistance. The Co(2-MeIm)MOF@CNF/GCE sensor exhibited a wide linear range from 10 to 1500 µM with a low limit of detection (LOD) of 89.6 nM and a high sensitivity of 107.3 µA mM
−1
cm
−2
. Importantly, as-developed Nb(BTC)MOF@CNF/GCE sensor is enabled to detect histamine in fish and banana samples stored for different periods of time, which thus indicates its practical viability as analytical histamine detector.
Journal Article
Electrospun Polymer Nanofibers: Processing, Properties, and Applications
Electrospun polymer nanofibers (EPNF) constitute one of the most important nanomaterials with diverse applications. An overall review of EPNF is presented here, starting with an introduction to the most attractive features of these materials, which include the high aspect ratio and area to volume ratio as well as excellent processability through various production techniques. A review of these techniques is featured with a focus on electrospinning, which is the most widely used, with a detailed description and different types of the process. Polymers used in electrospinning are also reviewed with the solvent effect highlighted, followed by a discussion of the parameters of the electrospinning process. The mechanical properties of EPNF are discussed in detail with a focus on tests and techniques used for determining them, followed by a section for other properties including electrical, chemical, and optical properties. The final section is dedicated to the most important applications for EPNF, which constitute the driver for the relentless pursuit of their continuous development and improvement. These applications include biomedical application such as tissue engineering, wound healing and dressing, and drug delivery systems. In addition, sensors and biosensors applications, air filtration, defense applications, and energy devices are reviewed. A brief conclusion is presented at the end with the most important findings and directions for future research.
Journal Article
Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites
In this study, three kinds of electrohydrodynamic atomization (EHDA) processes (electrospraying, electrospinning, and coaxial electrospinning) are implemented to create hydroxypropyl methylcellulose (HPMC) based ultra‐thin products for providing the fast dissolution of a poorly water‐soluble drug ketoprofen (KET). An EHDA apparatus, characterized by a novel spinneret, is homemade for conducting the three processes. The three types of products are electrospun nanofibers E1, electrosprayed microparticles E2, and core‐shell nanofibers E3. SEM and TEM results indicate that they have the anticipated morphologies and inner structures. X‐ray diffraction and Fourier Transform Infrared results verify that KET is mainly amorphous in all the composites due to its fine compatibility with HPMC. In vitro dissolution tests demonstrate that the drug rapid release performances has an order of E3>E1>E2≫KET powders. The fast dissolution mechanisms are suggested and the advantages of the three products are compared. The super performance of E3 in furnishing the rapid release is attributed to a synergistic action of small size (of the shell thickness), high porosity, amorphous state of drug, and the solubility of HPMC. EHDA nanostructures can support the development of nano drug delivery systems (DDSs) through tailoring the spatial distribution of drug molecules within the nano products.
Journal Article
Integrating Optical Nanofibres with Cold Rubidium Ground-State and Rydberg Atoms
In recent years, optical nanofibres have become a promising platform for trapping, manipulating and controlling atomic systems. In this work, I will highlight our recent work on the demonstration of multiphoton processes using optical nanofibres embedded in a Rb MOT for the generation of entangled photons and the excitation of Rydberg atoms for all-fibred quantum networks.
Journal Article
Protein/CaCO₃/Chitin Nanofiber Complex Prepared from Crab Shells by Simple Mechanical Treatment and Its Effect on Plant Growth
A protein/CaCO3/chitin nanofiber complex was prepared from crab shells by a simple mechanical treatment with a high-pressure water-jet (HPWJ) system. The preparation process did not involve chemical treatments, such as removal of protein and calcium carbonate with sodium hydroxide and hydrochloric acid, respectively. Thus, it was economically and environmentally friendly. The nanofibers obtained had uniform width and dispersed homogeneously in water. Nanofibers were characterized in morphology, transparency, and viscosity. Results indicated that the shell was mostly disintegrated into nanofibers at above five cycles of the HPWJ system. The chemical structure of the nanofiber was maintained even after extensive mechanical treatments. Subsequently, the nanofiber complex was found to improve the growth of tomatoes in a hydroponics system, suggesting the mechanical treatments efficiently released minerals into the system. The homogeneous dispersion of the nanofiber complex enabled easier application as a fertilizer compared to the crab shell flakes.
Journal Article