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Basic and advanced statistical tests : writing results sections and creating tables and figures
\"This book focuses on extraction of pertinent information from statistical test outputs, in order to write result sections and/or accompanying tables and/or figures. Each chapter provides the name of a basic or advanced statistical test, a brief description, examples of when to use each, a sample scenario, and a sample results section write-up. Depending on the test and need, most chapters provide a table and/or figure to accompany the write-up.\"--Provided by publisher.
Book
Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses
Many analyses of observational data are attempts to emulate a target trial. The emulation of the target trial may fail when researchers deviate from simple principles that guide the design and analysis of randomized experiments. We review a framework to describe and prevent biases, including immortal time bias, that result from a failure to align start of follow-up, specification of eligibility, and treatment assignment. We review some analytic approaches to avoid these problems in comparative effectiveness or safety research.
Journal Article
Survey of laboratory-acquired infections around the world in biosafety level 3 and 4 laboratories
Laboratory-acquired infections due to a variety of bacteria, viruses, parasites, and fungi have been described over the last century, and laboratory workers are at risk of exposure to these infectious agents. However, reporting laboratory-associated infections has been largely voluntary, and there is no way to determine the real number of people involved or to know the precise risks for workers. In this study, an international survey based on volunteering was conducted in biosafety level 3 and 4 laboratories to determine the number of laboratory-acquired infections and the possible underlying causes of these contaminations. The analysis of the survey reveals that laboratory-acquired infections have been infrequent and even rare in recent years, and human errors represent a very high percentage of the cases. Today, most risks from biological hazards can be reduced through the use of appropriate procedures and techniques, containment devices and facilities, and the training of personnel.
Journal Article
Conducting educational research
\"Conducting Educational Research is geared to help students understand and apply the most important principles of scholarly investigation. Now in its 6th edition, this research textbook includes updates such as a completely rewritten Chapter 12, a chapter devoted to statistical research without having to use the expensive program SPSS. The text has been revised throughout to include recent technological advances, simpler exercises, and visual elements to help the student understand the research process\"-- Provided by publisher.
Book
Stop this waste of people, animals and money
Predatory journals are easy to please. They seem to accept papers with little regard for quality, at a fraction of the cost charged by mainstream open-access journals. These supposedly scholarly publishing entities are murky operations, making money by collecting fees while failing to deliver on their claims of being open access and failing to provide services such as peer review and archiving.
Journal Article
Foundations of agnostic statistics
\"The last three decades have seen a marked change in the manner in which quantitative empirical inquiry in the social and health sciences is conducted. Sometimes dubbed the \"credibility revolution,\" this change has been characterized by a growing acknowledgment that the evidence that researchers adduce for their claims is often predicated on unsustainable assumptions. Our understanding of statistical and econometric tools has needed to change accordingly. We have found that conventional textbooks, which often begin with incredible modeling assumptions, are not well suited as a starting point for credible research\"-- Provided by publisher.
Book
Misreporting of Results of Research in Psychiatry
Abstract
Few studies address publication and outcome reporting biases of randomized controlled trials (RCTs) in psychiatry. The objective of this study was to determine publication and outcome reporting bias in RCTs funded by the Stanley Medical Research Institute (SMRI), a U.S. based, non-profit organization funding RCTs in schizophrenia and bipolar disorder. We identified all RCTs (n = 280) funded by SMRI between 2000 and 2011, and using non-public, final study reports and published manuscripts, we classified the results as positive or negative in terms of the drug compared to placebo. Design, outcome measures and statistical methods specified in the original protocol were compared to the published manuscript. Of 280 RCTs funded by SMRI between 2000 and 2011, at the time of this writing, three RCTs were ongoing and 39 were not performed. Among the 238 completed RCTs, 86 (36.1%) reported positive and 152 (63.9%) reported negative results: 86% (74/86) of those with positive findings were published in contrast to 53% (80/152) of those with negative findings (P < .001). In 70% of the manuscripts published, there were major discrepancies between the published manuscript and the original RCT protocol (change in the primary outcome measure or statistics, change in a number of patient groups, 25% or more reduction in sample size). We conclude that publication bias and outcome reporting bias is common in papers reporting RCTs in schizophrenia and bipolar disorder. These data have major implications regarding the validity of the reports of clinical trials published in the literature.
Journal Article
A practical approach to using statistics in health research : from planning to reporting
\"This book provides an outline with methodological steps of how to use statistics to analyze your research data. The book begins with a general introduction, which discusses what you should be trying to achieve with your statistical analysis. This involves describing the subjects you investigated and their outcomes, determining whether there is statistically significant evidence of differences in outcomes between groups of subjects, quantitatively describing effect sizes, and also determining whether any changes are large enough to be of clinical significance. Next, the authors cover data types and choosing statistical tests. This includes identifying the factor and outcome, and also identifying the type of data used to record the outcome. Readers are then introduced to multiple testing, the Chi-square test, and independent samples and the two-sample t-test. The Man-Whitney test is discussed, as well as the One-way ANOVA. Readers are taught how to Carrying out the Kruskal-Wallis test and the McNemar's test. The Paired t-test is covered, as well as how to carry out the Wilcoxon paired samples test. Readers are shown how to carry out the repeated measures ANOVA and the Friedman test. This includes discussion of merits of change in median, change in proportions in categories, and changes in high/low categories. The book concludes with a discussion on correlation and regression methods, and a detailed analysis on Cronbach's alpha\"-- Provided by publisher.
Book
Registry-based randomized controlled trials- what are the advantages, challenges, and areas for future research?
Registry-based randomized controlled trials are defined as pragmatic trials that use registries as a platform for case records, data collection, randomization, and follow-up. Recently, the application of registry-based randomized controlled trials has attracted increasing attention in health research to address comparative effectiveness research questions in real-world settings, mainly due to their low cost, enhanced generalizability of findings, rapid consecutive enrollment, and the potential completeness of follow-up for the reference population, when compared with conventional randomized effectiveness trials. However several challenges of registry-based randomized controlled trials have to be taken into consideration, including registry data quality, ethical issues, and methodological challenges. In this article, we summarize the advantages, challenges, and areas for future research related to registry-based randomized controlled trials.
Journal Article