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Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses
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Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses
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Journal Article
Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses
2016
Overview
Many analyses of observational data are attempts to emulate a target trial. The emulation of the target trial may fail when researchers deviate from simple principles that guide the design and analysis of randomized experiments. We review a framework to describe and prevent biases, including immortal time bias, that result from a failure to align start of follow-up, specification of eligibility, and treatment assignment. We review some analytic approaches to avoid these problems in comparative effectiveness or safety research.
Publisher
Elsevier Inc,Elsevier Limited
