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Journey to the Metaverse : technologies propelling business opportunities
The Metaverse will be the next technological revolution. This book helps business executives to understand its foundations and reveals the new opportunities it will bring. The accessible language used to explain the complex technologies involved is key to understanding the business opportunities that the Metaverse will bring. The book follows a smooth but thorough journey along all aspects associated with the Metaverse, from augmented reality, virtual reality, digital currencies, the Internet of things, 3D glasses, and many others. This book contains trustful, actionable, and practical insight from the experience of a person highly involved in technical activities and used to speak to the board of many corporations. Reading this book, you will understand not only the drivers behind the Metaverse but also the following milestones and the roadmap we can expect: an early insight to adapt your business strategy or professional career to get the most out of this new social paradigm.
Book
Theory of Critical Distances - A New Perspective in Fracture Mechanics
Critical distance methods are extremely useful for predicting fracture and fatigue in engineering components and represent an important development in the theory of fracture mechanics. Despite being in use for over fifty years in some fields, there has never been a book about these methods until now. The increasing use of computer-aided stress analysis has made these methods extremely easy to use in practical situations. This is turn has prompted researchers to re-examine the underlying theory with renewed interest. The book begins with a general introduction to the phenomena of mechanical failure in materials. After a simple explanation of how to use critical distance methods, and a more detailed exposition of the methods including their history and classification, the book continues by showing examples of how critical distance approaches can be applied to predict fracture and fatigue in different classes of materials. Subsequent chapters include some more complex theoretical areas, such as multiaxial loading and contact problems, and a range of practical examples using case studies of real engineering components. This book will be of interest to academic researchers, industrial engineers and research students.
eBook
It had to be you
Years after their parents' murder, identical twin brothers, determined to clear one name at the expense of the other, ask Laura Moran and her Under Suspicion crew to solve this brutal crime and as they get close to the truth, they find the danger from the past finding its way into the present.
Book
Mechanical complications in patients with ST-segment elevation myocardial infarction: A single centre experience
The study aims to assess characteristics and outcomes of patients suffering a mechanical complication (MC) after ST-segment elevation myocardial infarction (STEMI) in a contemporary cohort of patients in the percutaneous coronary intervention era.
This retrospective single-center cohort study encompasses 2508 patients admitted with STEMI between March 9, 2009 and June 30, 2014. A total of 26 patients (1.1%) suffered a mechanical complication: ventricular septal rupture (VSR) in 17, ventricular free wall rupture (VFWR) in 2, a combination of VSD and VFWR in 2, and papillary muscle rupture (PMR) in 5 patients. Older age (74.5 ± 10.4 years versus 63.9 ± 13.1 years, p < 0.001), female sex (42.3% versus 23.3%, p = 0.034), and a longer latency period between symptom onset and angiography (> 24h: 42.3% versus 16.2%, p = 0.002) were more frequent among patients with MC as compared to patients without MC. The majority of MC patients had multivessel disease (77%) and presented in cardiogenic shock (Killip class IV: 73.1%). Nine patients (7 VSR, 2 VFWR & VSR) were treated conservatively and died. Out of the remaining 10 VSR patients, four underwent surgery, three underwent implantation of an occluder device, and another three patients had surgical repair following occluder device implantation. All patients with isolated VFWR and PMR underwent emergency surgery. At 30 days, mortality for VSR, VFWR, VFWR & VSR and PMR amounted to 71%, 50%, 100% and 0%, respectively.
Despite advances in the management of STEMI patients, mortality of mechanical complications stays considerable in this contemporary cohort. Older age, female sex, and a prolonged latency period between symptom onset and angiography are associated with the occurrence of these complications.
Journal Article
Banyan Moon : a novel
\"Three Vietnamese American women mourning the death of the family matriarch recount their lives and childhoods at a crumbling, gothic manor called Banyan House, where the secrets of her grandmother's past come to light\"-- Provided by publisher.
Book
Nonoperative or Surgical Treatment of Acute Achilles’ Tendon Rupture
In this multicenter trial involving patients with acute Achilles’ tendon rupture, surgery (open repair or minimally invasive surgery) did not result in better outcomes than nonoperative treatment at 12 months.
Journal Article
The space between here & now
Perfect for fans of They Both Die at the End and You've Reached Sam, this gripping, atmospheric YA novel follows a teen with a mysterious condition that transports her to the past when she smells certain scents linked to specific memories. Seventeen-year-old Aimee Roh has Sensory Time Warp Syndrome, a rare condition that causes her to time travel to a moment in her life when she smells something linked to that memory. Her dad is convinced she'll simply grow out of it if she tries hard enough, but Aimee's fear of vanishing at random has kept her from living a normal life. When Aimee disappears for nine hours into a memory of her estranged mom--a moment Aimee has never remembered before--she becomes distraught. Not only was this her longest disappearance yet, but the memory doesn't match up with the story of how her mom left--at least, not the version she's always heard from her dad. Desperate for answers, Aimee travels to Korea, where she unravels the mystery of her memories, the truth about her mother, and the reason she keeps returning to certain moments in her life. Along the way, she realizes she'll need to reconcile her past in order to save her present. From acclaimed author Sarah Suk comes an aching, powerful exploration of memory, grief, and the painful silences we must overcome to discover our truest selves.
Book
Cost-effectiveness analysis of surgical versus non-surgical management of acute Achilles tendon ruptures
Purpose
An Achilles tendon rupture is a common injury that typically affects people in the middle of their working lives. The injury has a negative impact in terms of both morbidity for the individual and the risk of substantial sick leave. The aim of this study was to investigate the cost-effectiveness of surgical compared with non-surgical management in patients with an acute Achilles tendon rupture.
Methods
One hundred patients (86 men, 14 women; mean age, 40 years) with an acute Achilles tendon rupture were randomised (1:1) to either surgical treatment or non-surgical treatment, both with an accelerated rehabilitation protocol (surgical
n
= 49, non-surgical
n
= 51). One of the surgical patients was excluded due to a partial re-rupture and five surgical patients were lost to the 1-year economic follow-up. One patient was excluded due to incorrect inclusion and one was lost to the 1-year follow-up in the non-surgical group. The cost was divided into direct and indirect costs. The direct cost is the actual cost of health care, whereas the indirect cost is the production loss related to the impact of the patient’s injury in terms of lost ability to work. The health benefits were assessed using quality-adjusted life years (QALYs). Sampling uncertainty was assessed by means of non-parametric boot-strapping.
Results
Pre-injury, the groups were comparable in terms of demographic data and health-related quality of life (HRQoL). The mean cost of surgical management was €7332 compared with €6008 for non-surgical management (
p
= 0.024). The mean number of QALYs during the 1-year time period was 0.89 and 0.86 in the surgical and non-surgical groups respectively. The (incremental) cost-effectiveness ratio was €45,855. Based on bootstrapping, the cost-effectiveness acceptability curve shows that the surgical treatment is 57% likely to be cost-effective at a threshold value of €50,000 per QALY.
Conclusions
Surgical treatment was more expensive compared with non-surgical management. The cost-effectiveness results give a weak support (57% likelihood) for the surgical treatment to be cost-effective at a willingness to pay per QALY threshold of €50,000. This is support for surgical treatment; however, additionally cost-effectiveness studies alongside RCTs are important to clarify which treatment option is preferred from a cost-effectiveness perspective.
Level of evidence
I.
Journal Article
Major functional deficits persist 2 years after acute Achilles tendon rupture
Purpose
The purpose of this prospective randomized controlled study was to evaluate the long-term results after an acute Achilles tendon rupture in patients treated surgically or non-surgically. The focus was to evaluate whether any improvements occurred between the one and 2-year evaluation.
Method
Eighty-one patients (67 men, 14 women) with a mean (SD) age of 42 (9.1) were included in this study. Forty-two patients were treated surgically, and 39 treated non-surgically otherwise the treatment was identical for the two groups. All patients were evaluated using the Achilles tendon Total Rupture Score (ATRS), the Physical Activity Scale (PAS) and validated functional tests one and 2 years after injury.
Results
There were significant functional deficits on the injured side compared with the contralateral side 2 years after Achilles tendon rupture, regardless of treatment. Only minor improvements, even though statistically significant, occurred between the 1- and 2-year evaluations. The physical activity level remained significantly reduced as compared with prior to injury, but the ATRS mean was relatively high in both groups (89 and 90).
Conclusion
This long-term follow-up indicates that the majority of patients with an Achilles tendon rupture have not fully recovered (in regards to symptoms, physical activity level and function) 2 years after injury regardless of surgical or non-surgical treatment. Furthermore, only minor improvements occur between the 1- and 2-year evaluations. This indicates that to enhance the final outcome the focus should be on improvements in treatment within the first year. The patients appear to have adjusted to their impairments since the patient-reported outcome is relatively high in spite of functional deficits and lower activity level compared with pre-injury.
Level of evidence
Prospective randomized study, Level I.
Journal Article
Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia
In this randomized trial involving fetuses with moderate left congenital diaphragmatic hernia, fetoscopic endoluminal tracheal occlusion at 30 to 32 weeks of gestation did not significantly increase survival to discharge from a NICU or reduce the need for oxygen supplementation at 6 months, and it increased the risks of preterm, prelabor rupture of membranes and preterm birth. The surgical technique is shown in an animated video.
Journal Article