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Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia

by Johnson, Anthony , Morini, Francesco , Benachi, Alexandra , Van Calster, Ben , Nicolaides, Kypros H , Persico, Nicola , Wielgoś, Mirosław , Gratacos, Eduard , Belfort, Michael , Gardener, Glenn J , Deprest, Jan A , Ville, Yves , Berg, Christoph , DeKoninck, Philip L.J

in Adult / Balloon Occlusion / Balloon Occlusion - adverse effects / Balloon Occlusion - instrumentation / Balloon Occlusion - methods / Birth / Birth Defects / Complications of Pregnancy / Confidence intervals / Diaphragm / Female / Fetal Membranes, Premature Rupture - epidemiology / Fetal Therapies / Fetal Therapies - adverse effects / Fetoscopy / Fetuses / Gestation / Gestational Age / Gynecology / Gynecology General / Hernia / Hernias / Hernias, Diaphragmatic, Congenital / Hernias, Diaphragmatic, Congenital - mortality / Hernias, Diaphragmatic, Congenital - therapy / Human health and pathology / Humans / Hypoplasia / Infants / Intensive care / Intention to Treat Analysis / Life Sciences / Neonatal care / Neonates / Neonatology / Obstetric Labor, Premature / Obstetric Labor, Premature - epidemiology / Obstetrics / Occlusion / Oxygen / Patient Acuity / Pediatrics / Pediatrics General / Postpartum period / Pregnancy / Pregnancy complications / Premature Birth / Premature Birth - epidemiology / Premature Rupture of Fetal Membranes / Rupture / Statistical analysis / Supplements / Surgery / Surgery General / Survival / Trachea / Trachea - surgery / Ventilators / Watchful Waiting / Womens health

2021

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Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia

2021

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Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia

2021

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Journal Article

Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia

Johnson, Anthony,

Morini, Francesco,

Benachi, Alexandra,

Van Calster, Ben,

Nicolaides, Kypros H,

Persico, Nicola,

Wielgoś, Mirosław,

Gratacos, Eduard,

Belfort, Michael,

Gardener, Glenn J,

Deprest, Jan A,

Ville, Yves,

Berg, Christoph,

DeKoninck, Philip L.J

2021

Overview

In this randomized trial involving fetuses with moderate left congenital diaphragmatic hernia, fetoscopic endoluminal tracheal occlusion at 30 to 32 weeks of gestation did not significantly increase survival to discharge from a NICU or reduce the need for oxygen supplementation at 6 months, and it increased the risks of preterm, prelabor rupture of membranes and preterm birth. The surgical technique is shown in an animated video.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Balloon Occlusion

/ Balloon Occlusion - adverse effects

/ Balloon Occlusion - instrumentation

/ Balloon Occlusion - methods

/ Birth

/ Birth Defects