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The Rough Guide to South Africa is the definitive guide to one of the world's most fascinating and varied countries. Discover the best the country has to offer with stunning photography, extensive maps, comprehensive listings and detailed practical information. With accommodation listings that range from the most sumptuous safari lodges to cheap and cheerful backpacker lodges in stunning coastal positions, there's something for every budget. In-depth coverage on South Africa's many nature reserves is complemented by an illustrated wildlife guide, to help you make the most of your time on safari. Whether you want to explore the country's big sights - from the wilds of Kruger National Park and the best spots for whale watching to Cape Town's vibrant dining scene - or to uncover its many hidden gems, such as the dramatic desert scenery of the Richtersveld, The Rough Guide to South Africa is your indispensible travelling companion. Make the most of your time on Earth[trademark] with The Rough Guide to South Africa.

Contemporary forms of living and dying in Swaziland cannot be understood apart from the global HIV/AIDS pandemic, according to anthropologist Casey Golomski. In Africa's last absolute monarchy, the story of 15 years of global collaboration in treatment and intervention is also one of ordinary people facing the work of caring for the sick and dying and burying the dead. Golomski's ethnography shows how AIDS posed challenging questions about the value of life, culture, and materiality to drive new forms and practices for funerals. Many of these forms and practices―newly catered funeral feasts, an expanded market for life insurance, and the kingdom's first crematorium―are now conspicuous across the landscape and culturally disruptive in a highly traditionalist setting. This powerful and original account details how these new matters of death, dying, and funerals have become entrenched in peoples' everyday lives and become part of a quest to create dignity in the wake of a devastating epidemic.

The only guide to include coverage of Lesotho and Swaziland. South Africa is a growing tourist destination. Includes detailed full-color maps.

The genus Atherimorpha White, 1915 is a Gondwanan relic, occurring in South America, Southern Africa and Australia. Females are rarely collected, and are not described for more than half of the known species. The female of Atherimorphalatipennis Stuckenberg, 1956 was collected for the first time in 2021 and is described here, along with a redescription of the male. We describe the differences from the male, with the reduced wings and poorly defined scutellum the most noteworthy. The female of A.latipennis represents the first recorded case of brachyptery in the family Rhagionidae. Possible drivers of brachyptery in Afrotropical Diptera are briefly discussed.The genus Atherimorpha White, 1915 is a Gondwanan relic, occurring in South America, Southern Africa and Australia. Females are rarely collected, and are not described for more than half of the known species. The female of Atherimorphalatipennis Stuckenberg, 1956 was collected for the first time in 2021 and is described here, along with a redescription of the male. We describe the differences from the male, with the reduced wings and poorly defined scutellum the most noteworthy. The female of A.latipennis represents the first recorded case of brachyptery in the family Rhagionidae. Possible drivers of brachyptery in Afrotropical Diptera are briefly discussed.

Rapid diagnosis of drug-resistant tuberculosis is important in determining proper management. This letter reports on limitations of the Xpert MTB/RIF assay in determining rifampin resistance in tuberculosis isolates in Swaziland. To the Editor: Tuberculosis is a major global health problem that has worsened with the increasing emergence of Mycobacterium tuberculosis (MTB) complex strains that are resistant to rifampin (RIF) and isoniazid. As recommended by the World Health Organization (WHO), the timely detection of drug resistance with the use of rapid molecular diagnostic tests, such as the Xpert MTB/RIF assay (Cepheid), is essential for appropriate treatment of patients with tuberculosis and for limiting the further spread of multidrug-resistant disease. 1 , 2 We used 24-loci mycobacterial interspersed repetitive unit–variable number tandem repeat (MIRU-VNTR) analysis and spoligotyping to perform classic genotypic analysis of MTB . . .

Mesoarchean magmatism is widespread on the eastern margin of the Kaapvaal Craton, but its origin is still poorly understood, mainly because geochemical data is rare. To shed some light on the source of this Mesoarchean magmatism and to relate different Mesoarchean volcanic sequences to each other, we provide major and trace element data as well as Hf-Nd isotope compositions of amphibolites sampled close to the Kubuta Ranch in south-central Eswatini. These amphibolites, so far, were of unknown correlation to any volcanic sequence in Eswatini or South Africa. Hence, the aim of our study is to characterize the mantle source composition of these volcanic rocks and, furthermore, to constrain their genetic relation to other volcanic sequences in Eswatini and South Africa. Our findings reveal that, based on coherent trace element patterns and similar Nd isotope characteristics, the Kubuta volcanic rocks can be genetically linked to the ca. 3.0 Ga Usushwana Igneous Complex in West-Central Eswatini and the ca. 2.9 Ga Hlagothi Complex located in the KwaZulu-Natal province. In contrast, the coeval ca. 3.0 Ga Nsuze and ca. 2.9 Ga Mozaan Groups (Pongola Supergroup) of south-central Eswatini and northern KwaZulu-Natal province have slightly enriched compositions compared to the newly sampled Kubuta volcanic rocks. Our results suggest that the Nsuze and Mozaan Groups were sourced from a primitive mantle reservoir, whereas the Usushwana, Hlagothi, and Kubuta mafic rocks were derived by melting of a more depleted mantle source comparable to that of modern depleted MORB. Furthermore, our assimilation-fractional crystallization (AFC) calculations and Nd isotope constraints reveal that some samples were contaminated by the crust and that the crustal contaminants possibly represent felsic rocks related to the ca. 3.5 Ga crust-forming event in the Ancient Gneiss Complex. Alternatively, melting of a metasomatized mantle or plume-lithospheric mantle interaction may also produce the trace element and isotopic compositions observed in the samples. From a synthesis of our geochemical observations and age data from the literature, we propose a refined petrogenetic model, for a continental flood basalt setting in a Mesoarchean large igneous province on the eastern Kaapvaal Craton. Our petrogenetic model envisages two magma pulses sourced from a primitive mantle reservoir that led to the formation of the Nsuze (first) and Mozaan (second) lavas. Conductive heating of ambient depleted mantle by the mantle plumes caused partial melting that led to the formation of the Usushwana Igneous Complex associated with the first magmatic event (Nsuze) and the Hlagothi Igneous Complex associated with the second magmatic event (Mozaan). However, due to lacking age data of sufficient resolution, it is not possible to affiliate the Kubuta lavas to either the first or the second magmatic event.

Abstract Background To better understand transmission dynamics, we characterized Plasmodium falciparum genetic diversity in Eswatini, where transmission is low and sustained by importation. Methods Twenty-six P. falciparum microsatellites were genotyped in 66% of confirmed cases (2014–2016; N = 582). Population and within-host diversity were used to characterize differences between imported and locally acquired infections. Logistic regression was used to assess the added value of diversity metrics to classify imported and local infections beyond epidemiology data alone. Results Parasite population in Eswatini was highly diverse (expected heterozygosity [HE] = 0.75) and complex: 67% polyclonal infections, mean multiplicity of infection (MOI) 2.2, and mean within-host infection fixation index (FWS) 0.84. Imported cases had comparable diversity to local cases but exhibited higher MOI (2.4 vs 2.0; P = .004) and lower mean FWS (0.82 vs 0.85; P = .03). Addition of MOI and FWS to multivariate analyses did not increase discrimination between imported and local infections. Conclusions In contrast to the common perception that P. falciparum diversity declines with decreasing transmission intensity, Eswatini isolates exhibited high parasite diversity consistent with high rates of malaria importation and limited local transmission. Estimates of malaria transmission intensity from genetic data need to consider the effect of importation, especially as countries near elimination. In contrast to the commonly held perception that P. falciparum diversity declines with decreasing transmission intensity, infections from Eswatini exhibited high parasite diversity consistent with high rates of malaria importation and limited local transmission.

Background. The performance of Plasmodium falciparum–specific histidine-rich protein 2–based rapid diagnostic tests (RDTs) to evaluate suspected malaria in low-endemicity settings has not been well characterized. Methods. Using dried blood spot samples from patients with suspected malaria at 37 health facilities from 2012 to 2014 in the low-endemicity country of Swaziland, we investigated the diagnostic accuracy of histidine-rich protein 2-based RDTs using qualitative polymerase chain reaction (PCR) (nested PCR targeting the cytochrome b gene) and quantitative PCR as reference standards. To explore reasons for false-negative and/or false-positive results, we used pfhrp2/3-specific PCR and logistic regression analyses of potentially associated epidemiological factors. Results. From 1353 patients, 93.0% of RDT-positive (n = 185) and 31.2% of RDT-negative samples (n = 340) were available and selected for testing. Compared with nested PCR, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of RDTs were 51.7%, 94.1%, 67.3%, and 89.1%, respectively. After exclusion of samples with parasite densities <100/μL, which accounted for 75.7% of false-negative results and 33.3% of PCR-detectable infections, the sensitivity, specificity, PPV, and NPV were 78.8%, 93.7%, 62.3%, and 97.1%. Deletions of pfhrp2 were not detected. False-positivity was more likely during the second year and was not associated with demographics, recent malaria, health facility testing characteristics, or potential DNA degradation. Conclusions. In the low-transmission setting of Swaziland, we demonstrated low sensitivity of RDT for malaria diagnosis, owing to an unexpectedly high proportion of low-density infection among symptomatic subjects. The PPV was also low, requiring further investigation. A more accurate point-of-care diagnostic may be needed to support malaria elimination efforts.

Background Cervical Cancer (CC) is the number one cancer among women in sub-Saharan Africa. Although CC is preventable, most women in developing countries do not have access to screening. Methods This cross-sectional study was conducted to determine the prevalence and risk factors for cervical lesions using visual inspection with acetic acid (VIA) among 112 HIV positive and 161 negative women aged 18–69 years. Results The presence of cervical lesions was greater among HIV positive (22.9%) than HIV negative women (5.7%; p  < 0.0001). In logistic models, the risk of cervical lesions among HIV positive women was 5.24 times higher when adjusted by age (OR 5.24, CI 2.31–11.88), and 4.06 times higher in a full model (OR 4.06, CI 1.61–10.25), than among HIV negative women. In the age-adjusted model women who had ≥2 lifetime sexual partners were 3 times more likely (OR 3.00, CI 1.02–8.85) to have cervical lesions compared to women with one lifetime partner and the odds of cervical lesions among women with a history of STIs were 2.16 greater (OR 2.16, CI 1.04–4.50) than among women with no previous STI. In the fully adjusted model women who had a previous cervical exam were 2.5 times more likely (OR 2.53, CI 1.06–6.05) to have cervical lesions than women who had not. Conclusions The high prevalence of HIV infection and the strong association between HIV and cervical lesions highlight the need for substantial scale-up of cervical screening to decrease the rate of CC in Swaziland.

Background Swaziland aims to eliminate malaria by 2020. However, imported cases from neighbouring endemic countries continue to sustain local parasite reservoirs and initiate transmission. As certain weather and climatic conditions may trigger or intensify malaria outbreaks, identification of areas prone to these conditions may aid decision-makers in deploying targeted malaria interventions more effectively. Methods Malaria case-surveillance data for Swaziland were provided by Swaziland’s National Malaria Control Programme. Climate data were derived from local weather stations and remote sensing images. Climate parameters and malaria cases between 2001 and 2015 were then analysed using seasonal autoregressive integrated moving average models and distributed lag non-linear models (DLNM). Results The incidence of malaria in Swaziland increased between 2005 and 2010, especially in the Lubombo and Hhohho regions. A time-series analysis indicated that warmer temperatures and higher precipitation in the Lubombo and Hhohho administrative regions are conducive to malaria transmission. DLNM showed that the risk of malaria increased in Lubombo when the maximum temperature was above 30 °C or monthly precipitation was above 5 in. In Hhohho, the minimum temperature remaining above 15 °C or precipitation being greater than 10 in. might be associated with malaria transmission. Conclusions This study provides a preliminary assessment of the impact of short-term climate variations on malaria transmission in Swaziland. The geographic separation of imported and locally acquired malaria, as well as population behaviour, highlight the varying modes of transmission, part of which may be relevant to climate conditions. Thus, the impact of changing climate conditions should be noted as Swaziland moves toward malaria elimination.