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J. A. Stargardt, Autographen aus allen Gebieten, Berlinjune 5-6, 2012 Sotheby's, Music, Continental and Russian Books and Manuscripts, London, May 29, 20 12 Sotheby \\DeLa Collection Musicale André 'Meyer, Paris, October 16-17, 2012 Sotheby's, Important Manuscripts, Letters and Memorabilia from the Family of Arturo Toscanini, London, November 28, 2012 Sotheby's, Music, Continental and Russian Books and Manuscripts, including Science and Medicine, London, November 28, 20 1 2 I begin in Berlin, where Stargardt offered a previously unknown letter from Beethoven's early years in Vienna for euro120,000. Caricatures by Lyser of Beethoven, Paganini, Hoffmann, and Lyser himself from 1833, sold at Sotheby's auction (October 16-17, 2012) Page from a contemporary manuscript score of the String Quartets, Opus 18, nos. 1, 2, and 5 in the hand of Ferdinand Piringer, sold at Sotheby's auction (November 28, 2012) In November 2012, Sotheby's, London, auctioned off some of the holdings from the family of the legendary conductor Arturo Tòscanini, who owned two Beethoven manuscripts. Sale amounts in this report include the buyer's premium, with approximate conversions to dollar amounts based on exchange rates listed by the auction houses on the date of sale.

In the 1950s, Giulio Cantoni solved one of the major problems in biochemistry: the mechanisms of methylation. At the time, scientists knew that molecules such as nucleic acids and neurotransmitters were methylated, but they did not know how. \"They only knew there had to be active methyl groups somewhere\", former colleague and US National Institutes of Health (NIH) scientist emeritus Louis Sokoloff told The Lancet. Cantoni was the one who found that the source of the methyl group was methionine, that there was an enzyme called methionine-activating enzyme that catalysed methionine's reaction with ATP to make S-adenosylmethionine [SAMe], and that that compound then transferred the methyl group. \"He worked it out beautifully and completely and unequivocably and it's a classic bit of work in biochemistry\", Sokoloff said.

Keeping Score: Beethoven's Eroica www. keep! ngscore.org The San Francisco Symphony and conductor Michael Tilson Thomas have produced a series of radio and television shows, Keeping Score, that explore a variety of classical masterpieces. The link above takes you to the main site for Keeping Score, where you can access radio shows and other content; if you go to \"Keeping Score on PBS\" to the right, you can access videos, including the episode on the Eroica. (The staff of the Beethoven Center assisted in the creation of the television episode and website.) Classical Notes www.cla5sicalnotes.net This is an impressive website created by an amateur music writer.