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Animals, diseases, and human health : shaping our lives now and in the future
\"This book explains how animals shape our lives and our health, providing evidence that a \"One Health\" approach is the only logical methodology for advancing human health in the future\"--Provided by publisher.
Book
Neuropathology, pathomechanism, and transmission in zoonotic Borna disease virus 1 infection: a systematic review
Borna disease, which is a severe encephalitis that primarily affects horses and sheep, has been recognised for over two centuries. Borna disease virus 1 (BoDV-1) has been identified as a cause of a predominantly fatal encephalitis in humans. Little scientific data exist regarding the virus' transmission, entry portal, and excretion routes. Lesional patterns, immunological responses, and pathogenetic mechanisms remain largely unexplored in both reservoir and dead-end hosts. This systematic review compiles current knowledge on these aspects and provides guidance for future research. PubMed, ScienceDirect, and EBSCO were searched for publications from Jan 1, 2000, to April 30, 2024. 823 records were found, of which 41 studies were included. This systematic review discusses BoDV-1 transmission, pathogenesis, histopathological changes, and immunology in both reservoir and dead-end hosts, with special regard for humans. The exact propagation mechanisms, entry portal, and viral spread within the CNS are not entirely clear in humans. Although more data exist in animals, much remains hypothetical. Future research should focus on identifying potential entry sites and viral spread in dead-end hosts, which could help to clarify the pathogenesis and lesion distribution in the CNS, thereby contributing to a better understanding of BoDV-1 infection in humans and parallels with animal infections.
Journal Article
Substantial spillover burden of rat hepatitis E virus in humans
The emergence of
Rocahepevirus ratti
genotype 1 (rat hepatitis E virus; rat HEV) in humans presents an unprecedented threat; however, the risk of rat HEV transmission to humans is not well understood. Here, we report the “Distinguishing Antibody Response Elicitation (DARE)” method, which distinguishes exposure to rat HEV. We use four study sets from China for large-scale population analysis: set 1 (hospital visit) and set 3 (ALT abnormality) from Yunnan province, a biodiversity hotspot, and set 2 (received physical examination) and set 4 (ALT abnormality) from Jiangsu province, a non-hotspot control region. rat HEV exposure risk is significantly higher in Yunnan, with 21.97% (190 of 865) in set 1 and 13.97% (70 of 501) in set 3, compared to 0.75% (9 of 1196) in Jiangsu’s set 2. Six spillover infections for rat HEV are identified in set 1, with one case of abnormal ALT. The rat-1d strains carried by rats are closely related to those human infections. Our study reveals the substantial spillover burden posed by rat HEV in biodiversity hotspots and highlights the utility of DARE method for proactive surveillance of public health emergencies.
Rat hepatitis E virus (HEV) can infect humans, but the extent of spillover isn’t well studied. Here the authors develop a serological test that distinguishes exposure to rat HEV from other HEV infection and show substantial spillover in a biodiversity hotspot in China. The method can support surveillance of rat HEV.
Journal Article
Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea
Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filovirus epidemiology. To characterise filovirus zoonotic exposure, we collected cross-sectional serum samples from bushmeat hunters (
n
= 498) in Macenta Prefecture Guinea, adjacent to the index site of the 2013 EBOV-Makona spillover event. We identified distinct immune signatures (20/498, 4.0%) to multiple EBOV antigens (GP, NP, VP40) using stepwise ELISA and Western blot analysis and, live EBOV neutralisation (5/20; 25%). Using comparative serological data from PCR-confirmed survivors of the 2013-2016 EBOV outbreak, we demonstrated that most signatures (15/20) were not plausibly explained by prior EBOV-Makona exposure. Subsequent data-driven modelling of EBOV immunological outcomes to remote-sensing environmental data also revealed consistent associations with intact closed canopy forest. Together our findings suggest exposure to other closely related filoviruses prior to the 2013-2016 West Africa epidemic and highlight future surveillance priorities.
In a serological analysis, Bore et al. utilise serum samples, collected from a cohort of individuals associated with bushmeat hunting and butchering, in the forested region of Guinea, a region close to the epicentre of the 2013–2016 West Africa Ebola virus disease epidemic.
Journal Article
Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact
Rocahepevirus ratti
(ratHEV) is now recognised as an emerging zoonotic cause of hepatitis E, entrenched in urban rodent populations and already implicated in more than 50 confirmed human cases across Asia and Europe. Spillover occurs even in the absence of reported rodent contact, pointing to indirect environmental routes that remain poorly defined. Most infections are self-limiting, but acute hepatitis can be severe or fatal, and in immunocompromised patients ratHEV can persist and progress to chronic hepatitis. The absence of specific serological assays and the suboptimal performance of current molecular protocols, compounded by the high genetic diversity of the virus, limit the sensitivity of case detection. These challenges, together with limited awareness among health professionals, mean that the true magnitude of ratHEV globally remains unknown. This Review synthesises current knowledge on ratHEV ecology, host range, molecular virology and clinical impact, and outlines priorities for improving diagnostics, surveillance and prevention strategies.
Rat hepatitis E virus is an emerging zoonotic pathogen increasingly linked to human acute and chronic hepatitis. This Review examines its ecology, molecular diversity and clinical relevance, and highlights priorities for improving diagnosis, surveillance and prevention.
Journal Article
Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023
Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020–2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.3.3.2/pdm09, 1B/human-like, and H3.1990.5), including three H1N1v, two H1N2v, two H3N2v and one H1v. Five H1v were closely related to pdm09 lineage, one H1v (H1N2v) grouped within 1B.2.3 clade, and the two H3v grouped within a clade composed exclusively of Brazilian H3 swIAV (clade H3.1990.5.1). Internal gene segments were closely related to H1N1pdm09 isolated from pigs. IAV variant rarely result in sustained transmission between people, however the potential to develop such ability is of concern and must not be underestimated. This study brings into focus the need for continuous influenza surveillance and timely risk assessment.
Journal Article
Parallel multi-criteria decision analysis for sub-national prioritization of zoonoses and animal diseases in Africa: The case of Cameroon
The use of multi-criteria decision analysis (MCDA) for disease prioritization at the sub-national level in sub-Sahara Africa (SSA) is rare. In this research, we contextualized MCDA for parallel prioritization of endemic zoonoses and animal diseases in The Adamawa and North regions of Cameroon. MCDA was associated to categorical principal component analysis (CATPCA), and two-step cluster analysis. Six and seven domains made of 17 and 19 criteria (out of 70) respectively were selected by CATPCA for the prioritization of zoonoses and animal diseases, respectively. The most influencing domains were “public health” for zoonoses and “control and prevention” for animal diseases. Twenty-seven zoonoses and 40 animal diseases were ranked and grouped in three clusters. Sensitivity analysis resulted in high correlation between complete models and reduced models showing the robustness of the simplification processes. The tool used in this study can be applied to prioritize endemic zoonoses and transboundary animal diseases in SSA at the sub-national level and upscaled at the national and regional levels. The relevance of MCDA is high because of its contextualization process and participatory nature enabling better operationalization of disease prioritization outcomes in the context of African countries or other low and middle-income countries.
Journal Article
The rising threat of Nipah virus: a highly contagious and deadly zoonotic pathogen
The Nipah virus (NiV) is a highly virulent zoonotic infectious agent that poses a significant threat to public health. The virus is characterized by its pleomorphic structure and a single-stranded negative-sense RNA genome. It encodes six structural proteins and three nonstructural proteins. Attachment glycoproteins play a crucial role in allowing the virus to attach to the host cell surface. The matrix protein facilitates the encapsidation of the viral genome and proteins, enabling the formation of mature viral particles. The virus can spread via different routes, including zoonotic spillover and human-to-human transmission. Clinical manifestations include mild respiratory illness and severe and fatal encephalitis. The case fatality rate of Nipah virus infection varies widely, ranging from 40 to 75%, and is regulated by factors such as healthcare availability and quality, the patient's condition, and the virulence of the infecting strain. NiV has been reported in Malaysia, Bangladesh, and India, with fruit bats serving as natural reservoirs. Early detection and prompt response are crucial for controlling outbreaks; however, these efforts are hindered by diagnostic challenges and delayed recognition. The World Health Organization has categorized NiV as a priority pathogen owing to its epidemic potential, recurrent outbreaks, and alarming mortality rates. The persistent transmission dynamics and genetic stability of the Nipah virus among fruit bats require immediate attention and coordinated global action. The present study reviews the epidemiology, clinical features, and modes of transmission of Nipah virus infection, its geographical distribution, and endemic regions, highlighting the challenges in managing disease outbreaks.
Journal Article
Host–virus association databases as tools for understanding viral spillover at varying scales
Large host–virus association databases are increasingly used to explore broad questions in disease ecology, particularly around host range, pathogen diversity, and the potential for spillover. While these databases have been instrumental in large-scale synthesis of host–pathogen biogeography and zoonotic risk, their potential role in addressing fine-scale questions about pathogen prevalence, maintenance, and transmission dynamics remains underexplored. In this study, we build on previous efforts to assess how different types of data, including both entries in databases and the original studies they draw from, can support targeted research on zoonotic spillover. We selected two zoonotic diseases, Ebola virus disease and Lassa fever, which are characterised by recurrent spillover events and outbreaks in sub-Saharan Africa. We searched the VIRION database for entries corresponding to the respective viral taxa, the genus Orthoebolavirus and the species Mammarenavirus lassaense , and used these entries as case studies. We evaluated the extent to which databases capture crucial contextual metadata, such as spatial and temporal resolution, negative results, and measures of viral load. Guided by a conceptual framework of factors that lead to spillover, we demonstrate that while host–virus databases are valuable for addressing high-level patterns, fine-scale investigations of spillover require specific studies with detailed epidemiological data. Our study adds to a growing body of literature offering practical recommendations for database users and managers and highlights how these tools can be used as starting points in spillover research.
Journal Article
Prevalence and subtype distribution of Blastocystis sp. isolates from poultry in Lebanon and evidence of zoonotic potential
Background
Blastocystis
sp. is a common protozoan parasite frequently identified in the digestive tract of humans and a large variety of animal hosts worldwide, including birds. It exhibits a large genetic diversity with the identification of 17 subtypes (STs), most of them with low host specificity. ST6 and ST7 were identified in birds and suggested to represent avian STs only in the context of scarce small-scale epidemiological surveys. Moreover, these two STs also account for a significant proportion of human infections whose zoonotic origin has never been clearly confirmed. Therefore, molecular screening of
Blastocystis
sp. was conducted by quantitative real-time PCR for fecal samples from poultry farms and their in-contact humans from slaughterhouses in Lebanon. In parallel, a control group consisting of patients hospitalized in the same geographical area and reporting no contact with poultry was also screened for the presence of the parasite.
Results
The overall prevalence of
Blastocystis
sp. was shown to reach around 32% in chicken samples and 65% in the farms screened. All the avian isolates were subtyped and belonged to either ST6 or ST7, with a large predominance of ST6. Fifty-four percent of slaughterhouse staff members were positive for
Blastocystis
sp. compared with a similar prevalence of 56% in hospitalized patients. ST3 was predominant in both human cohorts followed by either ST1 then ST2 among slaughterhouse staff or by ST2 then ST1 among hospitalized patients. ST6 was also identified in two slaughterhouse workers and not in the group of hospitalized patients. Gene sequence identity was observed between chicken and human ST6 isolates from the same slaughterhouse.
Conclusions
Our data revealed a high prevalence of
Blastocystis
sp. in chicken samples and confirmed that ST6 and ST7 represented avian-adapted STs. Among both human cohorts,
Blastocystis
sp. infection was shown to exceed 50% with a predominance of ST3. The identification of ST6 in slaughterhouse staff members confirmed the zoonotic transmission of this ST through repeated and direct contact between chickens and their handlers.
Journal Article