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Emerging evidence has shown that p53 gene participates in human carcinogenesis as tumor suppressors. Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis. It has been suggested that p53 codon72 Arg/Pro polymorphism is associated with susceptibility to hepatocellular carcinoma (HCC). However, published results are inconsistent and inconclusive. To examine the validity of the association between the polymorphism and HCC risk, we performed this meta-analysis. We have conducted a search of case–control studies on the associations of p53 codon72 polymorphism with susceptibility to HCC in PubMed, ScienceDirect, BioMed central, Springer, EBSCO, Wanfang databases, and Chinese National Knowledge Infrastructure databases. A total of 15 studies were identified with 3,704 cases and 4,559 controls for codon72 Arg/Pro polymorphism. The result did support a significant genetic association between Pro allele and susceptibility to HCC in all the genetic models. Similarly, subgroup analysis showed significant associations between the Arg/Pro polymorphism and susceptibility to HCC when stratifying by race, gender, source of controls, and hepatitis virus infection status. This meta-analysis suggests that p53 codon72 Arg/Pro polymorphism may be associated with the risk of HCC, especially in subgroup analysis of Asian and Caucasian population, hospital-based population, the female, and the individuals infected with hepatitis virus. However, well-designed studies based on different ethnic groups with larger sample size and more detailed data are needed to confirm these conclusions.

目的利用meta分析的斤法系统评价p53 codon72多态性与官颈痛发病风险的关系。方法检索1998～2004年Medline、Elsevier、Evidence-Based Medicine Reviews、Ovid、中国期刊网、维普科技期刊数据库等，语种不限。并追溯检索获得的已发表文献及我们研究组未发表的文献。纳入标准：涉及p53 codon72基因型频率的独立病例对照研究，各文献研究方法相似，有综合的统计指标。剔除不符合纳入标准的，重复研究报告及数据不完整的文献。用RevMan4.2软件进行统汁分析。结果将总研究按病理组织学类型及种族和地域进行亚组分析，亚洲人群宫颈上皮内瘤样变（CIN）哑组和欧洲人群（主要为白种人）CIN亚组分析显示与其对照组无统计学差异。亚洲人群宫颈鳞癌（SCC）哑组合并OR=1.28，95％CI=1.05～1.55。欧洲人群SCC亚组合并OR=1.45，95％CI=1.08～1.95，P〈0.01，有统计学意义。结论p53 codon72 Arg／Arg基因型未能增加亚洲人群和欧洲人群官颈癌前期病变发生的危险性，但与浸润性宫颈癌发病风险有正向弱相关性。