Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
9,038
result(s) for
"entrapment"
Sort by:
Judgment : a novel
\"It was nothing more than a one-night stand. Juliana Brody, a judge in the Superior Court of Massachusetts, is rumored to be in consideration for the federal circuit and maybe, someday, the highest court in the land. At a conference in a Chicago hotel, she meets a gentle, vulnerable man and has an unforgettable night with him--something she's never done before. They part with an explicit understanding that this must never happen again. But back home in Boston, Juliana realizes that this was no random encounter. The man from Chicago proves to have an integral role in a case she's presiding over--a sex-discrimination case that's received national attention. Juliana discovers that she's been entrapped, her night of infidelity captured on video. Strings are being pulled in high places, a terrifying unfolding conspiracy that will turn her life upside down. But soon it becomes clear that personal humiliation, even the possible destruction of her career, are the least of her concerns, as her own life and the lives of her family are put in mortal jeopardy. In the end, turning the tables on her adversaries will require her to be as ruthless as they are\"-- Provided by publisher.
Book
Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges
In the last few decades, several natural bioactive agents have been widely utilized in the treatment and prevention of many diseases owing to their unique and versatile therapeutic effects, including antioxidant, anti-inflammatory, anticancer, and neuroprotective action. However, their poor aqueous solubility, poor bioavailability, low GIT stability, extensive metabolism as well as short duration of action are the most shortfalls hampering their biomedical/pharmaceutical applications. Different drug delivery platforms have developed in this regard, and a captivating tool of this has been the fabrication of nanocarriers. In particular, polymeric nanoparticles were reported to offer proficient delivery of various natural bioactive agents with good entrapment potential and stability, an efficiently controlled release, improved bioavailability, and fascinating therapeutic efficacy. In addition, surface decoration and polymer functionalization have opened the door to improving the characteristics of polymeric nanoparticles and alleviating the reported toxicity. Herein, a review of the state of knowledge on polymeric nanoparticles loaded with natural bioactive agents is presented. The review focuses on frequently used polymeric materials and their corresponding methods of fabrication, the needs of such systems for natural bioactive agents, polymeric nanoparticles loaded with natural bioactive agents in the literature, and the potential role of polymer functionalization, hybrid systems, and stimuli-responsive systems in overcoming most of the system drawbacks. This exploration may offer a thorough idea of viewing the polymeric nanoparticles as a potential candidate for the delivery of natural bioactive agents as well as the challenges and the combating tools used to overcome any hurdles.
Journal Article
Correction: Electrospun polycaprolactone (PCL)-amnion nanofibrous membrane prevents adhesions and promotes nerve repair in a rat model of sciatic nerve compression
[This corrects the article DOI: 10.1371/journal.pone.0244301.].[This corrects the article DOI: 10.1371/journal.pone.0244301.].
Journal Article
Fluctuation of steel–slag interface in flexible thin slab casting mold
In order to examine the flow state of the steel–slag interface in a thin slab mold at high casting speed, a flexible thin slab casting mold and a novel five-hole nozzle were investigated. The maximum velocity and fluctuation height of the steel–slag interface in the mold served as the evaluation criteria. Numerical simulation techniques, including large eddy simulation and volume of fluid, were employed to develop a two-phase flow model of liquid steel and slag. This model facilitated the analysis of the fluctuation behavior of the steel–slag interface and the mechanisms of slag entrapment. The results indicated that maintaining the stability of the steel–slag interface could be achieved by ensuring that the maximum velocity did not exceed 0.30 m s
−1
or that the wave height remained below 30 mm. The relationship between the maximum velocity and wave height of the steel–slag interface was established by analyzing different casting speeds. Slag entrapment occurred when the maximum velocity exceeded the critical value. The critical velocity for shear slag entrapment was 0.485 m s
−1
, while for vortex slag entrapment, it was when the velocity of the swirl center reached 0.235 m s
−1
. Electromagnetic braking proved effective in controlling flow in the mold, reducing fluctuations in the steel–slag interface, preventing slag entrapment, and maintaining the position of the interface. Furthermore, it facilitated the control of the uniformity and stability of slag movement along the outer wall of the submerged entry nozzle and the copper wall of the mold.
Journal Article
Using Microbial Aggregates to Entrap Aqueous Phosphorus
The increasing use and associated loss of phosphorus to the environment pose risks to aquatic ecosystems. Technology for phosphorus removal based on microbial aggregates is a natural, ecologically widespread, and sustainable reclamation strategy. Two main processes dominate phosphorus removal by microbial aggregates: extra- and intra-cellular entrapment. Extracellular phosphorus entrapment relies on extracellular polymeric substances, while intracellular entrapment uses a wider variety of phosphorus-entrapping mechanisms. In microbial aggregates, microalgae–bacteria interactions, quorum sensing, and acclimation can enhance phosphorus removal. Based on these insights, we propose novel avenues for entrapping phosphorus using ecological and genetic engineering, manipulated interactions, and integrated processes to create phosphorus removal technology mediated by microbial aggregates.
Phosphorus (P) entrapment by microbial aggregates is a natural process that requires relatively small amounts of operational inputs and is eco-friendly; it offers an effective means to remove P from eutrophic surface waters.Extracellular polymeric substances in microbial aggregates play an important role in extracellular P entrapment due to their inherent characteristics, chemical composition, and role in aggregation.Multiple mechanisms allow intracellular P entrapment by microalgae and polyphosphate-accumulating microorganisms in microbial aggregates.In microbial aggregates, microalgae–bacteria interactions, quorum sensing, and adaption can enhance the community’s ability to remove P.Ecological and genetic engineering, regulation of interactions, and integrated processes (microbial aggregates with enhanced biological P removal and bioelectrochemical system), can help to design P removal technology based on microbial aggregates.
Journal Article
Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in aqueous solution
We report hyperpolarized Xe signal advancement by metal-organic framework (MOF) entrapment (Hyper-SAME) in aqueous solution. The 129Xe NMR signal is drastically promoted by entrapping the Xe into the pores of MOFs. The chemical shift of entrapped 129Xe is clearly distinguishable from that of free 129Xe in water, due to the surface and pore environment of MOFs. The influences from the crystal size of MOFs and their concentration in water are studied. A zinc imidazole MOF, zeolitic imidazole framework-8 (ZIF-8), with particle size of 110 nm at a concentration of 100 mg/mL, was used to give an NMR signal with intensity four times that of free 129Xe in water. Additionally, Hyper-SAME is compatible with hyperpolarized 129Xe chemical exchange saturation transfer. The 129Xe NMR signal can be amplified further by combining the two techniques. More importantly, Hyper-SAME provides a way to make detection of hyperpolarized 129Xe in aqueous solution convenient and broadens the application area of MOFs.
Journal Article
DNA loop extrusion by human cohesin
Eukaryotic genomes are folded into loops and topologically associating domains, which contribute to chromatin structure, gene regulation, and gene recombination. These structures depend on cohesin, a ring-shaped DNA-entrapping adenosine triphosphatase (ATPase) complex that has been proposed to form loops by extrusion. Such an activity has been observed for condensin, which forms loops in mitosis, but not for cohesin. Using biochemical reconstitution, we found that single human cohesin complexes form DNA loops symmetrically at rates up to 2.1 kilo–base pairs per second. Loop formation and maintenance depend on cohesin’s ATPase activity and on NIPBL-MAU2, but not on topological entrapment of DNA by cohesin. During loop formation, cohesin and NIPBL-MAU2 reside at the base of loops, which indicates that they generate loops by extrusion. Our results show that cohesin and NIPBL-MAU2 form an active holoenzyme that interacts with DNA either pseudo-topologically or non-topologically to extrude genomic interphase DNA into loops.
Journal Article
Mental health and well-being during the COVID-19 pandemic: longitudinal analyses of adults in the UK COVID-19 Mental Health & Wellbeing study
The effects of coronavirus disease 2019 (COVID-19) on the population's mental health and well-being are likely to be profound and long lasting.
To investigate the trajectory of mental health and well-being during the first 6 weeks of lockdown in adults in the UK.
A quota survey design and a sampling frame that permitted recruitment of a national sample was employed. Findings for waves 1 (31 March to 9 April 2020), 2 (10 April to 27 April 2020) and 3 (28 April to 11 May 2020) are reported here. A range of mental health factors was assessed: pre-existing mental health problems, suicide attempts and self-harm, suicidal ideation, depression, anxiety, defeat, entrapment, mental well-being and loneliness.
A total of 3077 adults in the UK completed the survey at wave 1. Suicidal ideation increased over time. Symptoms of anxiety, and levels of defeat and entrapment decreased across waves whereas levels of depressive symptoms did not change significantly. Positive well-being also increased. Levels of loneliness did not change significantly over waves. Subgroup analyses showed that women, young people (18-29 years), those from more socially disadvantaged backgrounds and those with pre-existing mental health problems have worse mental health outcomes during the pandemic across most factors.
The mental health and well-being of the UK adult population appears to have been affected in the initial phase of the COVID-19 pandemic. The increasing rates of suicidal thoughts across waves, especially among young adults, are concerning.
Journal Article