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Endoluminal vacuum therapy using Endosponge is a new endoscopic method to treat extraperitoneal anastomotic leakage following low anterior resections or Hartmann\"s stump leakage in the lesser pelvis, at an early stage and with no reintervention. It is realized a continuous drainage of the secretion and the sponge cleans away the fibrin coatings, reduces in size and cleans the cavity. Methods The Endosponge seems an effective minimally invasive procedure to treat extraperitoneal anastomotic leakage without reintervention reducing morbidity and mortality.

Tissue engineering has emerged as a new treatment approach for bone repair and regeneration seeking to address limitations associated with current therapies, such as autologous bone grafting. While many bone tissue engineering approaches have traditionally focused on synthetic materials (such as polymers or hydrogels), there has been a lot of excitement surrounding the use of natural materials due to their biologically inspired properties. Fibrin is a natural scaffold formed following tissue injury that initiates hemostasis and provides the initial matrix useful for cell adhesion, migration, proliferation, and differentiation. Fibrin has captured the interest of bone tissue engineers due to its excellent biocompatibility, controllable biodegradability, and ability to deliver cells and biomolecules. Fibrin is particularly appealing because its precursors, fibrinogen, and thrombin, which can be derived from the patient's own blood, enable the fabrication of completely autologous scaffolds. In this article, we highlight the unique properties of fibrin as a scaffolding material to treat bone defects. Moreover, we emphasize its role in bone tissue engineering nanocomposites where approaches further emulate the natural nanostructured features of bone when using fibrin and other nanomaterials. We also review the preparation methods of fibrin glue and then discuss a wide range of fibrin applications in bone tissue engineering. These include the delivery of cells and/or biomolecules to a defect site, distributing cells, and/or growth factors throughout other pre-formed scaffolds and enhancing the physical as well as biological properties of other biomaterials. Thoughts on the future direction of fibrin research for bone tissue engineering are also presented. In the future, the development of fibrin precursors as recombinant proteins will solve problems associated with using multiple or single-donor fibrin glue, and the combination of nanomaterials that allow for the incorporation of biomolecules with fibrin will significantly improve the efficacy of fibrin for numerous bone tissue engineering applications.

Fibrin is a promising natural polymer that is widely used for diverse applications, such as hemostatic glue, carrier for drug and cell delivery, and matrix for tissue engineering. Despite the significant advances in the use of fibrin for bioengineering and biomedical applications, some of its characteristics must be improved for suitability for general use. For example, fibrin hydrogels tend to shrink and degrade quickly after polymerization, particularly when they contain embedded cells. In addition, their poor mechanical properties and batch-to-batch variability affect their handling, long-term stability, standardization, and reliability. One of the most widely used approaches to improve their properties has been modification of the structure and composition of fibrin hydrogels. In this review, recent advances in composite fibrin scaffolds, chemically modified fibrin hydrogels, interpenetrated polymer network (IPN) hydrogels composed of fibrin and other synthetic or natural polymers are critically reviewed, focusing on their use for tissue engineering.

Hintergrund: Thrombusmigration (TM) bei Patienten mit akuten Media (MCA)- Verschlussen fuhrt zu geringeren Raten kompletter Reperfusionen (TICI 3) nach mechanischer Thrombektomie. In der vorliegenden Studie soll geklart werden, ob die histologische Thrombuszusammensetzung Einfluss auf die TM hat. Methoden: 64 Patienten mit MCA-Verschlussen wurden eingeschlossen. In 17.2% der Falle wurde eine TM festgestellt. Die mittels Stentretriever-Verfahren gewonnenen MCA-Thromben wurden histologisch untersucht und die relativen Anteile von Erythrozyten, Leukozyten und Fibrin-Plattchen-Aggregaten erhoben. Ergebnisse: Erythrozyten-reiche (\"rote\") Thromben (mindestens 60%) neigten starker zur TM als Erythrozyten-arme (\"weisse\") (36.4% vs. 5.7%, p = 0.003). TM wurde haufiger bei diip-'n-ship als bei direkt zu uberwiesenen Patienten beobachtet (90.9% vs. 41.5%, p = 0.003). Zusammenfassung: Die TM scheint durch die histologische Thrombuszusammensetzung beeinflusst, wobei rote Thromben hierbei starker zur TM neigen als weisse Thromben. Mogliche Konsequenzen fur das endovaskulare Therapiekonzept werden diskutiert.