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Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison
Abstract
The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.
Journal Article
Networks of the brain
Olaf Sporns presents an overview of network approaches to neuroscience in which he explores the origins of brain complexity & the link between brain structure & function.
Book
Dopamine-Induced Dysconnectivity Between Salience Network and Auditory Cortex in Subjects With Psychotic-like Experiences: A Randomized Double-Blind Placebo-Controlled Study
Dopamine is involved in the pathophysiology of schizophrenia. Disrupted salience processing by the salience network (SN) may be a central link between dysregulated dopamine function and psychotic symptoms. However, dopaminergic influence on the SN and its presumed influence on psychotic and subpsychotic symptoms or psychotic-like experiences in healthy individuals remain unclear. Therefore, we investigated dopamine-induced changes in functional connectivity of the right anterior insula (rAI), a central SN hub, and their association with psychotic-like experiences. We enrolled 54 healthy, right-handed male subjects in a randomized, double-blind, cross-sectional placebo-controlled experiment. Psychotic-like experiences were assessed using the revised Exceptional Experiences Questionnaire (PAGE-R). They then received either placebo (n = 32) or 200 mg L-DOPA (n = 33), a dopamine precursor, orally and underwent resting-state functional magnetic resonance imaging. In a seed-to-voxel approach, we analyzed dopamine-induced changes in functional connectivity of the rAI and assessed the relationship between functional connectivity changes and PAGE-R score. L-DOPA reduced functional connectivity between the rAI and the left auditory cortex planum polare. In the placebo group, we found a strong negative correlation between PAGE-R score and rAI to planum polare functional connectivity; in the L-DOPA group, there was a strong positive correlation between PAGE-R score and functional connectivity between rAI and planum polare. The PAGE-R score explained about 30% of the functional connectivity variation between rAI and planum polare in the two groups. Our findings suggest that psychotic-like experiences are associated with dopamine-induced disruption of auditory input to the SN, which may lead to aberrant attribution of salience.
Journal Article
Building web applications with Visual Studio 2017 : using .NET Core and modern JavaScript frameworks
\"Learn how to build web applications from three Microsoft MVPs. You will be able to compare and contrast several frameworks and select the best one for your needs. With the release of .NET Core and Visual Studio 2017, you can deploy applications to multiple operating systems. And with the rising popularity of JavaScript UI frameworks, you can choose whether to stay with ASP.NET Core MVC or use a JavaScript framework. Building Web Applications with Visual Studio 2017 shows you how to build a site in Core MVC, and the three most popular JavaScript frameworks: Angular 2, React, and Aurelia. What You Will Learn: * Build a data access layer with Entity Framework Core * Build a RESTful service with ASP.NET Core MVC * Build a website with ASP.NET Core MVC and Bootstrap * Build the same website in Angular 2, React, and Aurelia. Who This Book Is For: Intermediate to advanced .NET developers.\"-- Provided by publisher.
Book
Transcranial photobiomodulation improves functional brain networks and working memory in healthy older adults: An fNIRS study
•Transcranial photobiomodulation (tPBM) has the potential to improve working memory in healthy older adults.•The mechanism of improving working memory by tPBM may be through alterations of the resting-state functional brain network properties.•The altered working memory were positively correlated with the changes of functional connectivity and nodal efficiency mainly in the left prefrontal cortex.•The tPBM may serve as an effective and non-invasive neurostimulation technique.
Transcranial photobiomodulation (tPBM), as a novel non-invasive neurostimulation technique, has shown the compelling potential for improving cognitive function in aging population. However, the potential mechanism remains unclear. Neuroimaging studies have found that tPBM-induced physiological changes exist in both targeted and non-targeted brain areas, suggesting the necessity of understanding the modulation mechanism from the perspective of the whole brain level.
This randomized, single-blind, sham-controlled crossover study aimed to investigate the hypothesis that tPBM improved working memory in healthy older adults through the mechanism of optimizing the properties of the resting-state functional brain networks.
A total of 55 right-handed healthy older adults were randomly assigned to sham tPBM session group or active tPBM session group. After a washout interval, they were assigned to the opposite intervention session. Each session included the following: active or sham tPBM application with a 1064-nm laser to the left forehead; before and after, resting-state functional near-infrared spectroscopy (fNIRS) measurements; and the digital n-back task. Differences in accuracy and reaction time of the n-back task, and changes in functional connectivity and graph metrics of the brain networks were investigated and compared between the active and sham tPBM sessions. In addition, correlations between tPBM-induced changes in functional brain networks, and the n-back task were examined.
The results showed that compared with the sham tPBM session, the accuracy and reaction time during 3-back task significantly improved in the active tPBM session. In addition, the global efficiency, local efficiency, nodal efficiency, and functional connectivity significantly increased in the active tPBM session, particularly in the frontoparietal areas. Importantly, the altered 3-back accuracy was positively correlated with the changes of functional connectivity and nodal efficiency mainly in left prefrontal cortex in those who had increased 3-back accuracy in the active tPBM session.
This study suggests that tPBM may serve as an effective tool to improve working memory in older adults through the modulation of resting-state functional brain network properties. Investigations in large-scale samples are needed to further validate the findings of this study.
Journal Article
.NET Core in action
.NET Core is a subset of the .NET framework with libraries and runtimes that drastically reduce its footprint, so you can write and run .NET applications more efficiently. .NET Core in Action shows .NET developers how to build professional software applications with .NET Core. By the end of this book, readers will be able to convert existing .NET code to work on multiple platforms or start new projects with knowledge of the tools and capabilities of .NET Core.
Book
Cholinergic and serotonergic modulation of resting state functional brain connectivity in Alzheimer's disease
Disruption of cholinergic and serotonergic neurotransmitter systems is associated with cognitive, emotional and behavioural symptoms of Alzheimer's disease (AD). To investigate the responsiveness of these systems in AD we measured the effects of a single-dose of the selective serotonin reuptake inhibitor citalopram and acetylcholinesterase inhibitor galantamine in 12 patients with AD and 12 age-matched controls on functional brain connectivity with resting state functional magnetic resonance imaging. In this randomized, double blind, placebo-controlled crossover study, functional magnetic resonance images were repeatedly obtained before and after dosing, resulting in a dataset of 432 scans. Connectivity maps of ten functional networks were extracted using a dual regression method and drug vs. placebo effects were compared between groups with a multivariate analysis with signals coming from cerebrospinal fluid and white matter as covariates at the subject level, and baseline and heart rate measurements as confound regressors in the higher-level analysis (at p < 0.05, corrected). A galantamine induced difference between groups was observed for the cerebellar network. Connectivity within the cerebellar network and between this network and the thalamus decreased after galantamine vs. placebo in AD patients, but not in controls. For citalopram, voxelwise network connectivity did not show significant group × treatment interaction effects. However, we found default mode network connectivity with the precuneus and posterior cingulate cortex to be increased in AD patients, which could not be detected within the control group. Further, in contrast to the AD patients, control subjects showed a consistent reduction in mean connectivity with all networks after administration of citalopram. Since AD has previously been characterized by reduced connectivity between the default mode network and the precuneus and posterior cingulate cortex, the effects of citalopram on the default mode network suggest a restoring potential of selective serotonin reuptake inhibitors in AD. The results of this study also confirm a change in cerebellar connections in AD, which is possibly related to cholinergic decline.
Journal Article
Dependency Injection : principles, practices, and patterns
\"Dependency Injection (DI) is a great way to reduce tight coupling between software components. Instead of hard-coding dependencies, such as specifying a database driver, you make those connections through a third party. Central to application frameworks like ASP.NET Core, DI enables you to better manage changes and other complexity in your software. \"Dependency injection: principles, practices, patterns\" is a revised and expanded edition of the bestselling classic \"Dependency Injection in .NET\". It teaches you DI from the ground up, featuring relevant examples, patterns, and anti-patterns for creating loosely coupled, well-structured applications. The well-annotated code and diagrams use C# examples to illustrate principles that work flawlessly with modern object-oriented languages and DI libraries.\"--Provided by publisher.
Book
The brain’s default network: updated anatomy, physiology and evolving insights
Discoveries over the past two decades demonstrate that regions distributed throughout the association cortex, often called the default network, are suppressed during tasks that demand external attention and are active during remembering, envisioning the future and making social inferences. This Review describes progress in understanding the organization and function of networks embedded within these association regions. Detailed high-resolution analyses of single individuals suggest that the default network is not a single network, as historically described, but instead comprises multiple interwoven networks. The multiple networks share a common organizational motif (also evident in marmoset and macaque anatomical circuits) that might support a general class of processing function dependent on internally constructed rather than externally constrained representations, with each separate interwoven network specialized for a distinct processing domain. Direct neuronal recordings in humans and monkeys reveal evidence for competitive relationships between the internally and externally oriented networks. Findings from rodent studies suggest that the thalamus might be essential to controlling which networks are engaged through specialized thalamic reticular neurons, including antagonistic subpopulations. These association networks (and presumably thalamocortical circuits) are expanded in humans and might be particularly vulnerable to dysregulation implicated in mental illness.
Journal Article