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TssW-PpkA-Fha axis controls the positioning and initiation of the type VI secretion system in Acidovorax citrulli
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TssW-PpkA-Fha axis controls the positioning and initiation of the type VI secretion system in Acidovorax citrulli
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Journal Article
TssW-PpkA-Fha axis controls the positioning and initiation of the type VI secretion system in Acidovorax citrulli
2025
Overview
How cells determine where to assemble a macromolecular complex is a fundamental question in biology since the localization of these complexes is directly linked to functions. In bacteria, the type VI secretion system (T6SS) relies on effective positioning to target competitor and host cells in contact-dependent interactions. This study identifies a PpkA-TssW-Fha axis that orchestrates T6SS localization and activation through membrane anchoring and liquid-liquid phase separation at the inner membrane interface. These new insights can help us not only better understand how the T6SS functions but also better design T6SS-based solutions for therapeutic targeting of drug-resistant and T6SS-susceptible bacterial and fungal pathogens.
Publisher
American Society for Microbiology
Subject
/ Bacterial Protein Secretion Mechanisms
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ E coli
/ Gene Expression Regulation, Bacterial
/ Genes
/ Kinases
/ LLPS
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ PpkA
/ Proteins
/ Role in Virulence and Host Interaction
/ Type VI Secretion System (T6SS)
/ Type VI Secretion Systems - genetics
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