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Multi-functional minor pilins coordinate type IV pilus assembly, adherence, motility, and DNA uptake in the pediatric pathogen Kingella kingae
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Multi-functional minor pilins coordinate type IV pilus assembly, adherence, motility, and DNA uptake in the pediatric pathogen Kingella kingae
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Multi-functional minor pilins coordinate type IV pilus assembly, adherence, motility, and DNA uptake in the pediatric pathogen Kingella kingae
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Journal Article
Multi-functional minor pilins coordinate type IV pilus assembly, adherence, motility, and DNA uptake in the pediatric pathogen Kingella kingae
2025
Overview
Kingella kingae is an emerging pediatric pathogen and a leading cause of osteoarticular infections in children 6 months to 4 years of age. To establish infection, K. kingae relies on T4P, dynamic surface structures that mediate host cell adherence, motility, and DNA uptake. T4P are expressed by a wide range of bacterial pathogens beyond K. kingae , including Pseudomonas aeruginosa , Neisseria gonorrhoeae , Neisseria meningitidis , and Legionella pneumophila , among others. The type IV pilus is composed of pilin subunits, including a major pilin that displays significant antigenic diversity and low-abundance minor pilins that are highly conserved. This study demonstrates the importance of eight minor pilins in K. kingae virulence properties. Given the conservation of minor pilins across diverse bacterial species, targeting minor pilin complexes may provide a foundation for a new class of broad-spectrum antivirulence therapies that prevent bacterial colonization and disease.
Publisher
American Society for Microbiology
Subject
/ Adhesins
/ DNA
/ Fimbriae Proteins - chemistry
/ Fimbriae Proteins - genetics
/ Fimbriae Proteins - metabolism
/ Fimbriae, Bacterial - genetics
/ Fimbriae, Bacterial - metabolism
/ Fimbriae, Bacterial - physiology
/ Genes
/ Genomes
/ Humans
/ Kingella kingae - metabolism
/ Kingella kingae - physiology
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Motility
/ Neisseriaceae Infections - microbiology
/ Operon
/ Pili
/ Pilin
/ Proteins
/ Structure-function relationships
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