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Thermodynamics shapes the in vivo enzyme burden of glycolytic pathways
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Thermodynamics shapes the in vivo enzyme burden of glycolytic pathways
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Journal Article
Thermodynamics shapes the in vivo enzyme burden of glycolytic pathways
2025
Overview
Cells regulate metabolic fluxes to balance energy production, biosynthesis, and the efficient use of limited resources, including the finite capacity for synthesizing and maintaining metabolic enzymes. Here, we present in vivo evidence that strongly thermodynamically favorable metabolic pathways require significantly fewer enzyme resources to sustain a given flux compared to less thermodynamically favorable pathways. These findings underscore the connection between pathway thermodynamics, resource allocation, and enzyme burden, providing valuable insights for metabolic engineering strategies aimed at optimizing pathways for high flux with minimal protein cost.
Publisher
American Society for Microbiology
Subject
/ Bacteria
/ Bacterial Proteins - metabolism
/ Clostridium thermocellum - enzymology
/ Clostridium thermocellum - metabolism
/ E coli
/ Enzymes
/ Escherichia coli - enzymology
/ Escherichia coli - metabolism
/ Ethanol
/ Glucose
/ Glycolysis and Central Carbon Metabolism
/ Kinases
/ Metabolic Networks and Pathways
/ Microbial Physiology and Genetics
/ Proteins
