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Novel dual regulatory roles of RpoA in quorum sensing regulation and social behavior switching in Pseudomonas aeruginosa
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Novel dual regulatory roles of RpoA in quorum sensing regulation and social behavior switching in Pseudomonas aeruginosa
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Journal Article
Novel dual regulatory roles of RpoA in quorum sensing regulation and social behavior switching in Pseudomonas aeruginosa
2026
Overview
To understand how bacterial populations function and evolve, it is essential to identify socially significant subpopulations, including previously unrecognized types of cheaters. In this study, we uncover an unexpected role of RNA polymerase (RNAP) in regulating quorum sensing (QS) and QS-associated social behaviors in P. aeruginosa . Specifically, we demonstrate that the α subunit of RNAP (RpoA) is a key regulatory component in this process. A single-nucleotide mutation within the C-terminal domain of RpoA was found to alter QS activity, driving an environment-dependent transition between cooperative and cheating phenotypes. This discovery of this novel, noncanonical QS cheater mutant offers new insights into intra-population interactions, population stability, and evolutionary dynamics. These findings carry significant implications for microbial ecology and deepen our understanding of social evolution in bacterial communities.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ DNA-Directed RNA Polymerases - genetics
/ DNA-Directed RNA Polymerases - metabolism
/ Gene Expression Regulation, Bacterial
/ Microbial Physiology and Genetics
/ Mutation
/ Pseudomonas aeruginosa - genetics
/ Pseudomonas aeruginosa - pathogenicity
/ Pseudomonas aeruginosa - physiology
/ Quorum Sensing and Regulation
/ Quorum Sensing and Virulence
/ Quorum Sensing in Gram-Negative Bacteria
/ Quorum Sensing Regulatory Networks
/ Quorum Sensing Signal Molecules
/ RNAP
/ RpoA
