Asset Details
Do you wish to reserve the book?
The conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces
Do you wish to request the book?
The conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The conserved two-component systems CutRS and CssRS control the protein secretion stress response in Streptomyces
2026
Overview
Streptomyces bacteria are the primary source of clinically useful antibiotics. While many two-component systems have been linked to antibiotic biosynthesis in Streptomyces species, few have been well characterized. Here, we characterize a secretion stress-sensing two-component system called CutRS and propose a model for how the sensor kinase detects extracellular protein misfolding via two highly conserved cysteine residues. Importantly, we also show that deletion of cutRS triggers antibiotic overproduction in the presence of glucose. Since glucose normally represses antibiotic biosynthesis in Streptomyces species through carbon catabolite repression, this finding reveals a simple genetic route to bypass this barrier. This has significant implications for antibiotic discovery pipelines and industrial production, where glucose-rich media are preferred for cost and scalability. Our results position CutRS as a key target for future strain-improvement strategies.
Publisher
American Society for Microbiology
Subject
/ Anti-Bacterial Agents - biosynthesis
/ Antibiotic and Secondary Metabolite Production
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biomass
/ Biotechnology and Synthetic Biology
/ Carbon
/ Cysteine
/ Gene Expression Regulation, Bacterial
/ Genes
/ Genetics and Molecular Biology
/ Genomes
/ Glucose
/ Kinases
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Proteins
/ Sensors
/ Streptomyces - growth & development
/ Streptomyces coelicolor - genetics
