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SYNTHESIS AND FUNCTION OF 3-PHOSPHORYLATED INOSITOL LIPIDS
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Journal Article
SYNTHESIS AND FUNCTION OF 3-PHOSPHORYLATED INOSITOL LIPIDS
2001
Overview
The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins.
Such interactions can affect the subcellular localization and aggregation of
target proteins, and through allosteric effects, their activity. Generation of
3-phosphoinositides has been documented to influence diverse cellular pathways
and hence alter a spectrum of fundamental cellular activities. This review is
focused on the 3-phosphoinositide lipids, the synthesis of which is acutely
triggered by extracellular stimuli, the enzymes responsible for their synthesis
and metabolism, and their cell biological roles. Much knowledge has recently
been gained through structural insights into the lipid kinases, their
interaction with inhibitors, and the way their 3-phosphoinositide products
interact with protein targets. This field is now moving toward a genetic
dissection of 3-phosphoinositide action in a variety of model organisms. Such
approaches will reveal the true role of the 3-phosphoinositides at the
organismal level in health and disease.
Publisher
Annual Reviews,Annual Reviews, Inc
Subject
1-Phosphatidylinositol 4-Kinase - chemistry
/ 1-Phosphatidylinositol 4-Kinase - metabolism
/ Androstadienes - pharmacology
/ Animals
/ Enzyme Inhibitors - pharmacology
/ Enzymes
/ Humans
/ Kinases
/ Lipids
/ Phosphatidylinositol 3-Kinases - antagonists & inhibitors
/ Phosphatidylinositol 3-Kinases - chemistry
/ Phosphatidylinositol 3-Kinases - metabolism
/ Phosphatidylinositols - chemistry
/ Phosphatidylinositols - metabolism
/ Phosphoric Monoester Hydrolases - metabolism
