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Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

by Lal, Himal , Heineman, Thomas C , Chlibek, Roman , Cunningham, Anthony L , Diez-Domingo, Javier , Watanabe, Daisuke , Zahaf, Toufik , Weckx, Lily , Godeaux, Olivier , Puig-Barberà, Joan , McElhaney, Janet E , Hwang, Shinn-Jang , Poder, Airi , Levin, Myron J , Vesikari, Timo

in Adjuvants / Adjuvants, Immunologic / Age / Aged / Antigens / Clinical trials / Double-Blind Method / Female / Glycoprotein E / Herpes viruses / Herpes zoster / Herpes Zoster - immunology / Herpes Zoster - prevention & control / Herpes Zoster Vaccine - administration & dosage / Herpes Zoster Vaccine - adverse effects / Herpes Zoster Vaccine - immunology / Humans / Immune response / Immunization / Injections, Intramuscular - adverse effects / Male / Middle Aged / Older people / Pain management / Treatment Outcome / Vaccination / Vaccine efficacy / Vaccines / Vaccines, Subunit - immunology / Varicella

2015

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Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

2015

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Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

2015

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Journal Article

Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults

Lal, Himal,

Heineman, Thomas C,

Chlibek, Roman,

Cunningham, Anthony L,

Diez-Domingo, Javier,

Watanabe, Daisuke,

Zahaf, Toufik,

Weckx, Lily,

Godeaux, Olivier,

Puig-Barberà, Joan,

McElhaney, Janet E,

Hwang, Shinn-Jang,

Poder, Airi,

Levin, Myron J,

Vesikari, Timo

2015

Overview

In this randomized, controlled trial involving more than 15,000 participants 50 years of age or older, a varicella–zoster virus subunit vaccine with AS01B adjuvant was found to have an efficacy of more than 96% in preventing herpes zoster. Herpes zoster, or shingles, results from the reactivation of latent varicella–zoster virus (VZV) in the dorsal-root or cranial-nerve ganglia, usually decades after primary infection. 1 , 2 Herpes zoster is characterized by a vesicular rash with a unilateral and dermatomal distribution and is almost always accompanied by pain. More than 90% of adults have been infected with VZV and are at risk for herpes zoster. 3 , 4 Although herpes zoster is most frequent in adults who are 50 years of age or older owing to immunosenescence, it can occur at any age, especially when cell-mediated immunity is decreased as a result of disease . . .

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Publisher

Massachusetts Medical Society

Subject

Adjuvants

/ Adjuvants, Immunologic

/ Age

/ Aged

/ Antigens

/ Clinical trials

/ Double-Blind Method