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Possible Ameliorative Properties of Tribulus Terrestris Extracts against Liver and Kidney Toxicity Caused By Ivermectin in Rats
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Possible Ameliorative Properties of Tribulus Terrestris Extracts against Liver and Kidney Toxicity Caused By Ivermectin in Rats
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Journal Article
Possible Ameliorative Properties of Tribulus Terrestris Extracts against Liver and Kidney Toxicity Caused By Ivermectin in Rats
2023
Overview
The current study sought to determine whether Tribulus terrestris fruit extracts could protect rats from hepato-renal damage brought on by ivermectin. To assess the effectiveness of Tribulus terrestris extracts against liver and renal toxicity as well as related histopathological alterations, vitamin \"C\" was employed as a comparison standard medication. Thirty rats were divided into two main groups; the first main group (6 rats) received a basal diet and used as the negative group. The second main group of 24 rats received ivermectin (IVM) (200 mg / kg of body weight) for 30 days in order to develop hepatic renal toxicity. Four separate groups were created from the second main group: Group 2 received a basal diet and used as the positive control group. Groups 3 and 4 consumed a basal diet in addition to oral Tribulus terrestris (TT) ethanolic and aqueous extracts (200 mg per kg of body weight), respectively. Group (5) consumed a basal diet along with oral vitamin \"C\" (200 mg per kilogram of body weight) for 28 days. Phenolic compounds in TT extract were identified using a high-performance gas chromatograph. The outcomes proved that groups of rats administered for 28 days with Tribulus terrestris extracts as well as vitamin \"C\" at a dose of 200 mg/Kg body weight have shown improvement in feed efficiency ratio body weight gain, feed intake, function of the kidneys and liver variables serum and urinary electrolytes (sodium and potassium), some immunological profiles (interleukin 6 and interleukin 10) and antioxidant enzymes activity. The group given Tribulus terrestris ethanolic extract (200mg/Kg body weight) had the best outcomes. The biochemical evaluation was corroborated by a histopathological investigation. According to the results of this investigation, Tribulus terrestris extracts could be utilized as a successful treatment to lessen the ivermectin induced liver and kidney damage in rats because they contain many phenolic antioxidant compounds.
Publisher
جامعة المنيا - كلية التربية النوعية
Subject
