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Pseudomonas aeruginosa- mediated cardiac dysfunction is driven by extracellular vesicles released during infection
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Journal Article
Pseudomonas aeruginosa- mediated cardiac dysfunction is driven by extracellular vesicles released during infection
2026
Overview
Bacterial pneumonia can lead to severe cardiovascular complications and is a major contributor to increased mortality among hospitalized patients, either directly or indirectly. Pseudomonas aeruginosa , an opportunistic pathogen frequently encountered in hospital settings, accounts for nearly 20% of all infections in intensive care units (ICUs). Our previous studies demonstrated that P. aeruginosa lung infection induces profound cardiac electrical abnormalities and left ventricular (LV) dysfunction, despite minimal bacterial dissemination to the heart. In the present study, we identify exosomes released from infected host cells and outer membrane vesicles (OMVs) secreted by P. aeruginosa as critical mediators of this cardiac dysfunction. We show that host-derived exosomes are enriched with bacterial OMVs containing toxins and other immunogenic molecules, which promote systemic inflammation and tissue injury, ultimately contributing to cardiac impairment.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Animals
/ Bacteria
/ Clinical Microbiology and Infectious Diseases
/ Exosomes
/ Extracellular Vesicles - metabolism
/ Healthcare-Associated Infections
/ human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
/ Humans
/ Induced Pluripotent Stem Cells
/ Lungs
/ Mice
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Myocytes, Cardiac - microbiology
/ outer membrane vesicles (OMVs)
/ Pseudomonas aeruginosa - pathogenicity
/ Pseudomonas aeruginosa - physiology
/ Pseudomonas Infections - complications
/ Pseudomonas Infections - microbiology
/ Sepsis and Systemic Infections
