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Modulation of bacterial cell size and growth rate via activation of a cell envelope stress response
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Modulation of bacterial cell size and growth rate via activation of a cell envelope stress response
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Journal Article
Modulation of bacterial cell size and growth rate via activation of a cell envelope stress response
2025
Overview
Bacteria must coordinate their growth rate, shape, and division to survive and flourish, yet how these cellular properties are maintained in the face of environmental stresses is poorly understood. Working with Escherichia coli , we show that activating the Rcs phosphorelay, an envelope stress-signaling system, in the absence of external stresses slows growth, shortens cells, and increases the concentration of the key division protein FtsZ, leading to more closely spaced division sites. Depleting the levels of IgaA, a regulator of the Rcs pathway, yielded similar phenotypes. However, activating Rcs via drug-induced cell-wall disruption did not affect growth rate, indicating that the physiological impact of this pathway depends on the context of activation. Our findings reveal links among cell growth, shape homeostasis, and cell envelope stress. Understanding this coupling further will provide new avenues to predict and modulate bacterial growth and physiology during stress.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Bacteria
/ Bacterial Cell Size and Volume
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Cytoskeletal Proteins - metabolism
/ E coli
/ Escherichia coli - drug effects
/ Escherichia coli - growth & development
/ Escherichia coli - physiology
/ Escherichia coli Proteins - genetics
/ Escherichia coli Proteins - metabolism
/ FtsZ
/ Gene Expression Regulation, Bacterial
/ Microbial Pathogenesis and Immunology
