Asset Details
Do you wish to reserve the book?
Staphylococcus aureus exhibits spatiotemporal heterogeneity in Sae activity during kidney abscess development
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Staphylococcus aureus exhibits spatiotemporal heterogeneity in Sae activity during kidney abscess development
Do you wish to request the book?
Staphylococcus aureus exhibits spatiotemporal heterogeneity in Sae activity during kidney abscess development
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Staphylococcus aureus exhibits spatiotemporal heterogeneity in Sae activity during kidney abscess development
2025
Overview
Infections with Staphylococcus aureus pose a serious public health threat due to high levels of antibiotic resistance and limited efficacy of alternative therapeutics. There has been a great deal of interest in developing novel therapeutics that target virulence factors essential during infection. However, it remains largely unknown if these factors are required at specific stages of the infection, and whether all bacterial cells or a limited subset express them. Here, we sought to examine virulence factor expression using fluorescent reporter strains that would indicate activity of two master regulators of virulence in S. aureus , Agr and Sae. While Agr appeared inactive during kidney abscess development, the Sae system exhibited heterogeneity, increased expression at later stages, and was required for abscess progression. These results provide critical information for the development of virulence factor-targeting strategies for kidney abscess treatment.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Animals
/ Bacteria
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Clinical Microbiology and Infectious Diseases
/ Gene Expression Regulation, Bacterial
/ Kidneys
/ Kinases
/ Methicillin-Resistant Staphylococcus Aureus (Mrsa)
/ Mice
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Mutants
/ Staphylococcal Infections - microbiology
/ Staphylococcal Infections - pathology
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - metabolism
/ Staphylococcus aureus - pathogenicity
/ Staphylococcus Aureus Pathogenesis
/ Trans-Activators - metabolism
