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Pericytes modulate endothelial inflammatory response during bacterial infection

by Ribeiro, Noelly Q. , Carvalho, Thaynara P. , Silva, Monique F. , Paixão, Tatiane A. , Lee, Jee-Yon , Santos, Renato L. , Lima, Pâmela A. , Toledo, Frank A. O. , Tsolis, Reneé M. , Bautista, Diego F. A. , Oliveira, Jefferson B. S. , Costa, Fabíola B. , Birbrair, Alexander

in Bacterial infections / Blood vessels / Brucella / CD31 antigen / Cell adhesion molecules / Cell death / Chemokines / Connexin 43 / Cytotoxicity / Endothelial cells / Endothelium / Host-Microbial Interactions / Immune response / Inflammation / Intercellular adhesion molecule 1 / Leukocytes / Ligands / Lipopolysaccharides / Listeria / Listeria monocytogenes / Microscopy / Neutrophils / Pathogens / Pericytes / Peritonitis / Research Article / Tumor necrosis factor-TNF

2024

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Pericytes modulate endothelial inflammatory response during bacterial infection

2024

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Pericytes modulate endothelial inflammatory response during bacterial infection

2024

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Journal Article

Pericytes modulate endothelial inflammatory response during bacterial infection

Ribeiro, Noelly Q.,

Carvalho, Thaynara P.,

Silva, Monique F.,

Paixão, Tatiane A.,

Lee, Jee-Yon,

Santos, Renato L.,

Lima, Pâmela A.,

Toledo, Frank A. O.,

Tsolis, Reneé M.,

Bautista, Diego F. A.,

Oliveira, Jefferson B. S.,

Costa, Fabíola B.,

Birbrair, Alexander

2024

Overview

A previously unknown mechanism by which pericytes modulate inflammation was discovered. The absence of pericytes or blocking interaction between pericytes and endothelium through connexin 43 results in stronger inflammation, which shifts our understanding of pericyte biology, from a structural cell to a player in controlling inflammation.

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Publisher

American Society for Microbiology

Subject

/ Cell adhesion molecules

/ Cell death

/ Chemokines