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The Staphylococcus aureus regulatory program in a human skin-like environment
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The Staphylococcus aureus regulatory program in a human skin-like environment
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Journal Article
The Staphylococcus aureus regulatory program in a human skin-like environment
2024
Overview
Staphylococcus aureus is the major cause of skin diseases, and its increased prevalence in skin colonization and infections present a need to understand its physiology in this environment. The work presented here outlines S. aureus upregulation of colonization and virulence factors using a newly developed medium that strives to replicate the human skin surface environment and demonstrates roles for adhesins clumping factor A (ClfA), serine-rich repeat glycoprotein adhesin (SraP), and the fibronectin binding proteins (Fnbps) in human corneocyte adherence.
Publisher
American Society for Microbiology
Subject
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Gene Expression Regulation, Bacterial
/ Glucose
/ Humans
/ Methicillin-Resistant Staphylococcus aureus - genetics
/ Methicillin-Resistant Staphylococcus aureus - physiology
/ Peptides
/ RNA-seq
/ Skin
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - growth & development
/ Staphylococcus aureus - pathogenicity
/ Staphylococcus aureus - physiology
