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Herpes simplex virus type 1 impairs mucosal-associated invariant T cells

by Abendroth, Allison , Purohit, Shivam K. , Fairlie, David P. , Traves, Renee , Mak, Jeffrey Y. W. , Stern, Lauren , Emanuel, Zoe , Corbett, Alexandra J. , Tscharke, David C. , Slobedman, Barry , Samer, Carolyn , Willis, Katherine

in Antigens / CD4 antigen / CD56 antigen / CD8 antigen / Cells, Cultured / Cytokine receptors / Cytokines / Cytotoxicity / Dengue fever / Fibroblasts / Flow cytometry / Herpes simplex / Herpes Simplex - immunology / Herpes Simplex - virology / herpes simplex virus / Herpes viruses / herpesvirus / Herpesvirus 1, Human - immunology / Herpesvirus 1, Human - physiology / Histocompatibility Antigens Class I - immunology / HSV / HSV-1 / Humans / Immunomodulation / Interleukin 12 / Interleukin 18 / Interleukin-18 - immunology / Lymphocytes / Lymphocytes T / MAIT cell / Major histocompatibility complex / Metabolites / Mucosa / Mucosal immunity / mucosal-associated invariant T cell / Mucosal-Associated Invariant T Cells - immunology / Mucosal-Associated Invariant T Cells - virology / Proteins / Research Article / T cell receptors / Tumor necrosis factor-TNF / Variance analysis / Viral infections / Virology / Viruses / Vitamin B

2025

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2025

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2025

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Journal Article

Herpes simplex virus type 1 impairs mucosal-associated invariant T cells

Abendroth, Allison,

Purohit, Shivam K.,

Fairlie, David P.,

Traves, Renee,

Mak, Jeffrey Y. W.,

Stern, Lauren,

Emanuel, Zoe,

Corbett, Alexandra J.,

Tscharke, David C.,

Slobedman, Barry,

Samer, Carolyn,

Willis, Katherine

2025

Overview

Mucosal-associated invariant T cells (MAIT cells) are “unconventional” immune cells that are becoming increasingly appreciated to play important roles in a variety of viral infections. Herpes simplex virus (HSV) causes significant human disease and is a master manipulator of multiple immune functions, but how this virus may control MAIT cells is poorly understood. We discovered that HSV can infect human MAIT cells and impair their functional capacity and also show that MAIT cells exposed to HSV, but which do not show evidence of infection, are similarly impaired. This study therefore identifies an additional immunomodulatory function of HSV.

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Publisher

American Society for Microbiology

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