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Lactobacillus plantarum Lac16 alleviates dextran sodium sulfate-induced colitis in mice by suppressing NLRP3 inflammasome overactivation through microbiota-derived isobutyric acid
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Lactobacillus plantarum Lac16 alleviates dextran sodium sulfate-induced colitis in mice by suppressing NLRP3 inflammasome overactivation through microbiota-derived isobutyric acid
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Lactobacillus plantarum Lac16 alleviates dextran sodium sulfate-induced colitis in mice by suppressing NLRP3 inflammasome overactivation through microbiota-derived isobutyric acid
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Journal Article
Lactobacillus plantarum Lac16 alleviates dextran sodium sulfate-induced colitis in mice by suppressing NLRP3 inflammasome overactivation through microbiota-derived isobutyric acid
2025
Overview
This study establishes that Lactobacillus plantarum Lac16 alleviates DSS-induced colitis through gut microbiota-dependent mechanisms. Lac16 administration significantly ameliorated colitis symptoms while restoring intestinal barrier integrity, promoting anti-inflammatory macrophage polarization, and suppressing NLRP3 inflammasome overactivation. The pseudo-germ-free mouse model provided definitive evidence that Lac16’s suppression of NLRP3 inflammasome overactivation requires gut microbiota. Fecal microbiota transplantation verified the causal role of microbiota in mediating Lac16’s therapeutic benefits. Notably, Lac16 reshaped microbial composition, elevating beneficial genera ( Alloprevotella and Dubosiella ) while suppressing pathogenic genera ( Bacteroides and Helicobacter ). Crucially, Lac16 increased microbiota-derived short-chain fatty acids, particularly isobutyric acid. Both in vivo and in vitro experiments confirmed that isobutyric acid significantly contributes to anticolitic effects and suppresses NLRP3 activation. These findings elucidate a novel mechanism by which Lac16 ameliorates colitis via (i) microbiota-dependent NLRP3 inflammasome modulation and (ii) isobutyric acid-mediated protective effects. This work provides important insights into probiotic mechanisms and supports targeting microbial metabolic networks for IBD intervention.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Animals
/ Antigens
/ Colitis
/ Colitis - chemically induced
/ Colon
/ Dextran
/ Dextran Sulfate - adverse effects
/ Diarrhea
/ Fecal Microbiota Transplantation
/ Gastrointestinal Microbiome - drug effects
/ Germfree
/ Host-Microbiome Interactions
/ Immune System Modulation by Microbiota
/ Lactobacillus plantarum - physiology
/ Lactobacillus plantarum Lac16
/ Male
/ Mice
/ Microbial Pathogenesis and Immunology
/ Microbiome and Barrier Function
/ Microbiome and Disease Susceptibility
/ Microbiome-Driven Inflammation
/ Mucosal Microbiota and Immune Interactions
/ NLR Family, Pyrin Domain-Containing 3 Protein - genetics
/ NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
/ Probiotics - administration & dosage
/ Proteins
