Asset Details
Do you wish to reserve the book?
The Edwardsiella T3SS effector EseQ promotes invasion by altering the cell’s cytoskeleton and disrupting the epithelial barrier
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Edwardsiella T3SS effector EseQ promotes invasion by altering the cell’s cytoskeleton and disrupting the epithelial barrier
Do you wish to request the book?
The Edwardsiella T3SS effector EseQ promotes invasion by altering the cell’s cytoskeleton and disrupting the epithelial barrier
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Edwardsiella T3SS effector EseQ promotes invasion by altering the cell’s cytoskeleton and disrupting the epithelial barrier
2025
Overview
Edwardsiella piscicida causes severe hemorrhagic septicemia in marine and freshwater fish worldwide, resulting in significant economic losses for the aquaculture industry (K. Y. Leung, Q. Wang, Z. Yang, and B. A. Siame, Virulence 10:555–567, 2019, https://doi.org/10.1080/21505594.2019.1621648 ). Our previous research identified a novel type III secretion system effector, EseQ, in E. piscicida whose function remains to be elucidated. In this work, we showed that EseQ binds to tubulin and GEF-H1 and destabilizes microtubules. GEF-H1 released from microtubules activates the RhoA-ROCK-MLCII signaling pathway, leading to stress fiber formation in epithelial cells. EseQ deforms the epithelial barrier and promotes E. piscicida ’s invasion in a stress fiber-dependent manner. This work contributes to the understanding of the mechanism by which E. piscicida invades host cells.
Publisher
American Society for Microbiology,American Society for Microbiology (ASM)
Subject
/ Animals
/ Bacterial Protein Secretion Mechanisms
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Cells
/ Edwardsiella - pathogenicity
/ Enterobacteriaceae Infections - microbiology
/ Epithelial Cells - microbiology
/ Guanine nucleotide exchange factor
/ Host Cell Invasion Mechanisms
/ Humans
/ invasion
/ Microbial Pathogenesis and Immunology
/ Microbial Physiology and Genetics
/ Proteins
/ Rho Guanine Nucleotide Exchange Factors - metabolism
/ Tubulin
/ Type Iii Secretion System (T3ss)
/ Type III Secretion Systems - genetics
