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Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation
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Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation
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Journal Article
Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation
2025
Overview
Tuberculosis is a devastating human disease that kills over 1.2 million people a year. This disease is caused by the bacterial pathogen Mycobacterium tuberculosis ( Mtb ). Mtb excels at surviving in the human host by entering a non-replicating, dormant state. The current work investigated the proteomic changes that Mtb undergoes in response to carbon starvation, a culture condition that models dormancy. The authors found broad effects of carbon starvation on the proteome, with the relative abundance of 37% of proteins significantly altered. Protein changes related to cell wall biosynthesis, metabolism, and drug susceptibility are discussed. Proteins associated with a carbon starvation phenotype are identified, and results are compared to other dormancy models, including hypoxia.
Publisher
American Society for Microbiology
