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BAFF AND APRIL: A Tutorial on B Cell Survival
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Journal Article
BAFF AND APRIL: A Tutorial on B Cell Survival
2003
Overview
BAFF, a member of the TNF family, is a fundamental survival factor for
transitional and mature B cells. BAFF overexpression leads to an expanded B
cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be
found in the serum of autoimmune patients. APRIL is a related factor that
shares receptors with BAFF yet appears to play a different biological role. The
BAFF system provides not only potential insight into the development of
autoreactive B cells but a relatively simple paradigm to begin considering the
balancing act between survival, growth, and death that affects all cells.
Publisher
Annual Reviews,Annual Reviews, Inc
Subject
/ B-Cell Activation Factor Receptor
/ Humans
/ Immunoglobulin A - metabolism
/ Ligands
/ Membrane Proteins - chemistry
/ Membrane Proteins - genetics
/ Membrane Proteins - metabolism
/ Mice
/ Receptors, Tumor Necrosis Factor - chemistry
/ Receptors, Tumor Necrosis Factor - genetics
/ Receptors, Tumor Necrosis Factor - metabolism
/ Tumor Necrosis Factor Ligand Superfamily Member 13
/ Tumor Necrosis Factor-alpha - chemistry
