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Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
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Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
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Journal Article
Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
2016
Overview
Doxorubicin (DOX) remains the most effective anticancer agent which is widely used in several adult and pediatric cancers, but its application is limited for its cardiotoxicity and hepatotoxicity. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for many diseases. In this study, we found that intraperitoneal injection of hydrogen-rich saline (H2 saline) ameliorated the mortality, cardiac dysfunction, and histopathological changes caused by DOX in rats. Meanwhile, serum brain natriuretic peptide (BNP), aspartate transaminase (AST), alanine transaminase (ALT), albumin (ALB), tissue reactive oxygen species (ROS), and malondialdehyde (MDA) levels were also attenuated after H2 saline treatment. What is more, we further demonstrated that H2 saline treatment could inhibit cardiac and hepatic inflammation and apoptosis relative proteins expressions by western blotting test. In conclusion, our results revealed a protective effect of H2 saline on DOX-induced cardiotoxicity and hepatotoxicity in rats by inhibiting inflammation and apoptosis.
Publisher
Hindawi Limiteds,Hindawi Publishing Corporation,John Wiley & Sons, Inc,Wiley
Subject
/ Animals
/ Anti-Inflammatory Agents - chemistry
/ Anti-Inflammatory Agents - therapeutic use
/ Aspartate Aminotransferases - blood
/ Cancer
/ Chemical and Drug Induced Liver Injury - drug therapy
/ Doxorubicin - adverse effects
/ Heart
/ Heart Injuries - chemically induced
/ Heart Injuries - drug therapy
/ Kinases
/ Male
/ Natriuretic Peptide, Brain - metabolism
/ Proteins
/ Rats
/ Reactive Oxygen Species - metabolism
/ Rodents
/ Sodium Chloride - therapeutic use
/ Studies
