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Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
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Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
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Journal Article
Anti-Inflammatory and Immunoregulatory Functions of Artemisinin and Its Derivatives
2015
Overview
Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring the unknown bioactivities of artemisinin derivatives. In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions.
Publisher
Hindawi Limiteds,Hindawi Publishing Corporation,John Wiley & Sons, Inc,Hindawi Limited,Wiley
Subject
/ Anti-Inflammatory Agents - chemistry
/ Arthritis, Rheumatoid - drug therapy
/ B-Lymphocytes - drug effects
/ Humans
/ Hypersensitivity - metabolism
/ Immunosuppressive Agents - chemistry
/ Lupus Erythematosus, Systemic - drug therapy
/ Malaria
/ Mice
/ Review
/ Structure-Activity Relationship
/ Studies
