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Cannabidiol Attenuates Pulmonary Arterial Hypertension by Normalizing the Mitochondrial Function in Vascular Smooth Muscle Cells
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Cannabidiol Attenuates Pulmonary Arterial Hypertension by Normalizing the Mitochondrial Function in Vascular Smooth Muscle Cells
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Paper
Cannabidiol Attenuates Pulmonary Arterial Hypertension by Normalizing the Mitochondrial Function in Vascular Smooth Muscle Cells
2020
Overview
Abstract Pulmonary artery hypertension (PAH) is a chronic disease associated with enhanced proliferation of pulmonary artery smooth muscle cells (PASMCs) and dysfunctional mitochondria, which was with limited therapeutic options. It has been proved that cannabidiol (CBD) had antioxidant effects in many cardiovascular diseases, whereas the efficacy of CBD in PAH is unknown. To defined the effect of CBD in PAH, we explored the functions of CBD in both PASMCs proliferation test in vitro, and preventive and therapeutic PAH rodent models in vivo. The roles of CBD in mitochondria function and the oxidant stress were assessed in human PASMCs and PAH mice. We found that CBD significantly inhibited hyperproliferation of hypoxia-induced PASMCs, and intragastrically administered CBD could reverse the pathological changes in both Sugen-hypoxia and MCT-induced PAH mice models. Mechanical analysis demonstrated that CBD alleviated PAH by recovering mitochondrial energy metabolism, normalizing the hypoxia-induced oxidant stress, inhibiting abnormal glycolysis and lactate accumulation in cannabinoids receptors-independent manner. Thus, CBD could be a potential drug for PAH. Figure1 Figure1 * Download figure * Open in new tab Competing Interest Statement The authors have declared no competing interest. * Abbreviation PAH pulmonary artery hypertension PASMCs pulmonary artery smooth muscle cells CBD cannabidiol ROS reactive oxygen species Nfe2l2 nuclear factor E2 related factor 2 Hmox-1 heme oxygenase 1 Sod superoxide dismutase Nqo1 quinone oxidoreductase 1 Cnr cannabinoids receptor TRPA1 transient receptor potential A1 PPARγ peroxisome proliferator-activated receptor GPR G Protein-Coupled Receptor Sugen vascular endothelial growth factor receptor blocker SU-5416 MCT monocrotaline RVSP right ventricular systolic pressure RVH right ventricular hypertrophy IHC immunohistochemical PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 OCR O2 consumption rate ECAR extracellular acidification rate DRP1 dynamin-1-like protein FIS1 mitochondrial fission 1 protein OPA1 optic atrophy type 1 (OPA1) MFN1/2 mitofusin 1/2 MIEF1 mitochondrial elongation factor 1 GR glutathione reductase GSH glutathione peroxidase MDA Malondialdehyde Keap1 Kelch-like ECH-associated protein 1 Glut1 Glucose transporter 1 PDK1 pyruvate dehydrogenase lipoamide kinase isozyme 1
