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Direct Allelic Variation Scanning of the Yeast Genome
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Direct Allelic Variation Scanning of the Yeast Genome
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Journal Article
Direct Allelic Variation Scanning of the Yeast Genome
1998
Overview
As more genomes are sequenced, the identification and characterization of the causes of heritable variation within a species will be increasingly important. It is demonstrated that allelic variation in any two isolates of a species can be scanned, mapped, and scored directly and efficiently without allele-specific polymerase chain reaction, without creating new strains or constructs, and without knowing the specific nature of the variation. A total of 3714 biallelic markers, spaced about every 3.5 kilobases, were identified by analyzing the patterns obtained when total genomic DNA from two different strains of yeast was hybridized to high-density oligonucleotide arrays. The markers were then used to simultaneously map a multidrug-resistance locus and four other loci with high resolution (11 to 64 kilobases).
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Biological and medical sciences
/ Chromosome Mapping - methods
/ Classical genetics, quantitative genetics, hybrids
/ Coding
/ Cycloheximide - pharmacology
/ DNA
/ Drug Resistance, Microbial - genetics
/ Drug Resistance, Multiple - genetics
/ Fundamental and applied biological sciences. Psychology
/ Genetics
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genomes
/ Genomics
/ Genotype
/ methods
/ Saccharomyces cerevisiae - genetics
/ strains
/ Vegetals
/ Yeast
/ Yeasts
