Paper

Bifidobacteria-mediated immune system imprinting early in life

Henrick, Bethany M, German, J Bruce, Pou, Christian, Brown, Heather K, Smilowitz, Jennifer T, Underwood, Mark A, Chen, Yang, Rodriguez, Lucie, Ehrlich, Amy M, Brodin, Petter, Tan, Ziyang, Ambrosiani, Ylva, Lakshmikanth, Tadepally, Mitchell, Ryan D, Olin, Axel, Chew, Stephanie, Gustafsson, Anna, Henckel, Ewa, Wang, Jun, Prambs, Johann, Constantin Habimana Mugabo, Mikes, Jaromir, Bohlin, Kajsa, Bernhardsson, Anna Karin, Frese, Steven A

2020

Overview

Bifidobacterium infantis EVC001 silenced intestinal Th2 and Th17 immune responses, while inducing IFNβ, and its metabolites skew T-cell polarization in vitro, from Th2 towards Th1, suggesting a healthier immune imprinting during the first critical months of life. HIGHLIGHTS An ordered sequence of immune changes after birth, driven by microbial interactions Low gut Bifidobacterium abundance is associated with markers of intestinal inflammation Feeding B. infantis EVC001 silenced intestinal Th2 and Th17 but upregulates IFNβ B. infantis EVC001 metabolites and/or enteric cytokines skew naïve T-cell polarization towards Th1 and away from Th2 Competing Interest Statement PB, JM and TL are founders and shareholders of Cytodelics AB (Stockholm, Sweden). PB is an advisor to Scailyte AG (Zurich, Switzerland). RDM, SC, JP, HKB, SAF, and BMH are employees of Evolve BioSystems, a company focused on restoring the infant microbiome. JTS received funding to conduct the IMPRINT trial and AME received funding to assist in writing the manuscript. JBG is a co-founder of Evolve BioSystems. SAF and BMH serve as Adjunct Assistant Professors in Food Science & Technology Department, University of Nebraska Lincoln. Footnotes * ↵12 Lead contact * Labels in Figure 4a-b were swapped in the original submission. These have been reversed and are now correct. Credit to Stephanie N Langel, Duke University for spotting this error (ref: @stephanielangel at Twitter). * https://brodinlab.com/data-repository/

• Publisher: Cold Spring Harbor Laboratory Press,Cold Spring Harbor Laboratory
• Subject: Cytokines / Helper cells / Immune imprinting / Immune response / Immunology / Imprinting / Intestine / Lymphocytes T / Metabolites / Microbiomes / Polarization / β-Interferon