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AB0160 GUT MICROBES AND SYSTEMIC SCLEROSIS: CAUSE OR CONSEQUENCE?
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AB0160 GUT MICROBES AND SYSTEMIC SCLEROSIS: CAUSE OR CONSEQUENCE?
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Journal Article
AB0160 GUT MICROBES AND SYSTEMIC SCLEROSIS: CAUSE OR CONSEQUENCE?
2023
Overview
BackgroundThere is growing evidence supporting an association between gut microbiota and the risk of systemic sclerosis (SSc)[1]. However, the causal relationship between gut microbiota and SSc remains ambiguous.ObjectivesA two-sample Mendelian randomization (MR) analysis was performed to reveal the causal relationship between gut microbiota and SSc.MethodsWe obtained data on intestinal flora from the MR-base website [2] and 218,499 samples for systemic sclerosis from the IEU database for a two-sample MR analysis. Inverse variance weighting, MR-Egger, and weighted median were used to examine the causal relationship between gut flora and SSc. Then a series of sensitivity analyses were performed to verify the robustness of the results. Finally, the bacteria which appeared causality with SSc were subjected to reverse MR analysis to assess the possibility of reverse causality.ResultsInverse variance-weighted estimates indicated that genus Collinsella (odds ratio(OR) = 8.982, 95% confidence interval(CI): 1.571-51.366，P = 0.014), phylum Actinobacteria (OR = 5.746, 95% CI: 1.247-26.491，P = 0.025), genus Ruminococcaceae (OR = 5.500, 95% CI: 1.477-20.477，P = 0.011) had a risk effect on SSc (Table 1). According to the results of the reverse MR analysis, SSc had no significant causal effect on intestinal flora. No significant heterogeneity or horizontal pleiotropy of instrumental variables was found.ConclusionThe present study revealed a causal relationship between three gut microflora genera and SSc, providing new insights into the mechanisms of gut microbiota-mediated scleroderma development.References[1]Lemos, M.P.C., et al., Dysbiosis and Gut Microbiota Modulation in Systemic Sclerosis. J Clin Rheumatol, 2022. 28(2): p. e568-e573.[2]Kurilshikov, A. and C. Medina-Gomez, Large-scale association analyses identify host factors influencing human gut microbiome composition. 2021. 53(2): p. 156-165.Table 1.Mendelian randomization analysis for the association between gut microbiota and SScSScN of SNPsCochran’s Q statistic(p-value)Odds ratio95% CIp-valueGenus CollinsellaInverse variance weighted93.853 (0.870)8.982(1.571，51.366)0.014MR Egger93.545 (0.8301)1.515(0.002，1029.541)0.904Weighted median914.103(1.466，135.692)0.022Phylum ActinobacteriaInverse variance weighted1517.720 (0.220)5.746(1.247,26.491)0.025MR Egger1516.880 (0.205)79.147(0.110, 57116.960)0.216Weighted median152.109(0.275,16.168)0.448Genus RuminococcaceaeInverse variance weighted126.317 (0.851)5.500(1.477,20.477)0.011MR Egger126.183 (0.800)2.552(0.034,191.160)0.680Weighted median125.698(1.009,32.173)0.052SSc, systemic sclerosis; MR, Mendelian randomization; CI, confidence intervalAcknowledgements:NIL.Disclosure of InterestsNone Declared.
Publisher
BMJ Publishing Group Ltd and European League Against Rheumatism,Elsevier B.V,Elsevier Limited
Subject
