Asset Details
Do you wish to reserve the book?
Renal Fibrosis : Collagen Composition and Assembly Regulates Epithelial-Mesenchymal Transdifferentiation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Renal Fibrosis : Collagen Composition and Assembly Regulates Epithelial-Mesenchymal Transdifferentiation
Do you wish to request the book?
Renal Fibrosis : Collagen Composition and Assembly Regulates Epithelial-Mesenchymal Transdifferentiation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Renal Fibrosis : Collagen Composition and Assembly Regulates Epithelial-Mesenchymal Transdifferentiation
2001
Overview
Type IV collagen is a major component of basement membranes and it provides structural and functional support to various cell types. Type IV collagen exists in a highly complex suprastructure form and recent studies implicate that protomer (the trimeric building unit of type IV collagen) assembly is mediated by the NC1 domain present in the C-terminus of each collagen alpha-chain polypeptide. Here we show that type IV collagen contributes to the maintenance of the epithelial phenotype of proximal tubular epithelial cells, whereas type I collagen promotes epithelial-to-mesenchymal transdifferentiation (EMT). In addition, the recombinant human alpha1NC1 domain inhibits assembly of type IV collagen NC1 hexamers and potentially disrupts the deposition of type IV collagen, facilitating EMT in vitro. Inhibition of type IV collagen assembly by the alpha1NC1 domain up-regulates the production of transforming growth factor-beta1 in proximal tubular epithelial cells, an inducer of EMT. These results strongly suggest that basement membrane architecture is pivotal for the maintenance of epithelial phenotype and that changes in basement membrane architecture potentially lead to up-regulation of transforming growth factor-beta1, which contributes to EMT during renal fibrosis.
Publisher
ASIP,American Society for Investigative Pathology
Subject
/ Cell Differentiation - physiology
/ Collagen Type IV - antagonists & inhibitors
/ Collagen Type IV - chemistry
/ Collagen Type IV - physiology
/ Epithelial Cells - pathology
/ Fibrosis
/ Humans
/ Kidney Tubules, Proximal - metabolism
/ Kidney Tubules, Proximal - pathology
/ Mice
/ Protein Structure, Tertiary - physiology
/ Recombinant Proteins - metabolism
/ Regular
