Asset Details
Do you wish to reserve the book?
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells
Do you wish to request the book?
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells
2007
Overview
A key issue in mammalian immunology is how CD4
+
CD25
+
Foxp3
+
regulatory T cells (T
reg
cells) suppress immune responses. Here we show that T
reg
cells induced apoptosis of effector CD4
+
T cells
in vitro
and
in vivo
in a mouse model of inflammatory bowel disease. T
reg
cells did not affect the early activation or proliferation of effector CD4
+
T cells. Cytokines that signal through the common γ-chain suppressed T
reg
cell–induced apoptosis. T
reg
cell–induced effector CD4
+
T cell death required the proapoptotic protein Bim, and effector CD4
+
T cells incubated with T
reg
cells showed less activation of the prosurvival kinase Akt and less phosphorylation of the proapoptotic protein Bad. Thus, cytokine deprivation–induced apoptosis is a prominent mechanism by which T
reg
cells inhibit effector T cell responses.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ CD4-Positive T-Lymphocytes - cytology
/ CD4-Positive T-Lymphocytes - immunology
/ CD4-Positive T-Lymphocytes - metabolism
/ Forkhead Transcription Factors - metabolism
/ Interleukin-2 Receptor alpha Subunit - analysis
/ Interleukin-2 Receptor alpha Subunit - metabolism
/ Mammals
/ Mice
