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Revisiting propafenone toxicity
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Journal Article
Revisiting propafenone toxicity
2017
Overview
Propafenone is a Vaughan Williams class 1c antiarrhythmic medication widely used for treatment of arrhythmias. Although the long-term safety of propafenone use has not been established, it is commonly used for treatment of atrial fibrillation in patients with no structural heart disease. Propafenone is well known as pill-in-the-pocket treatment for its effect in terminating paroxysmal episodes of atrial fibrillation. Herein, we discuss an unusual adverse reaction to propafenone in a patient who presented with symptomatic bradycardia and hypotension. The aim of this article is to increase physician awareness for propafenone toxicity and its management, with a focused literature review on propafenone pharmacotherapy.
Publisher
BMJ Publishing Group Ltd,BMJ Publishing Group LTD,BMJ Case Reports
Subject
/ Aged
/ Anti-Arrhythmia Agents - adverse effects
/ Bradycardia - chemically induced
/ Dopamine
/ Enzymes
/ Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect
/ Humans
/ Hypotension - chemically induced
/ Male
/ Nausea
/ Pacing and electrophysiology
/ Patients
/ Propafenone - adverse effects
/ Sinuses
/ Sodium
/ Toxicity
/ White
