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Diffuse large B cell lymphoma with superimposed lung abscess: potential role for intracavitary fibrinolytic therapy through a percutaneous drain to facilitate lung abscess drainage
by
Kern, Ryan
, Nelson, Darlene
, Mullon, John
, Chae, June
in
Abscesses
/ Antibiotics
/ Case reports
/ Chemotherapy
/ Fistula
/ Infections
/ Lymphoma
/ Medical imaging
/ Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
/ Thrombolytic drugs
2018
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Diffuse large B cell lymphoma with superimposed lung abscess: potential role for intracavitary fibrinolytic therapy through a percutaneous drain to facilitate lung abscess drainage
by
Kern, Ryan
, Nelson, Darlene
, Mullon, John
, Chae, June
in
Abscesses
/ Antibiotics
/ Case reports
/ Chemotherapy
/ Fistula
/ Infections
/ Lymphoma
/ Medical imaging
/ Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
/ Thrombolytic drugs
2018
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Diffuse large B cell lymphoma with superimposed lung abscess: potential role for intracavitary fibrinolytic therapy through a percutaneous drain to facilitate lung abscess drainage
by
Kern, Ryan
, Nelson, Darlene
, Mullon, John
, Chae, June
in
Abscesses
/ Antibiotics
/ Case reports
/ Chemotherapy
/ Fistula
/ Infections
/ Lymphoma
/ Medical imaging
/ Novel Treatment (New Drug/Intervention; Established Drug/Procedure in New Situation)
/ Thrombolytic drugs
2018
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Diffuse large B cell lymphoma with superimposed lung abscess: potential role for intracavitary fibrinolytic therapy through a percutaneous drain to facilitate lung abscess drainage
Journal Article
Diffuse large B cell lymphoma with superimposed lung abscess: potential role for intracavitary fibrinolytic therapy through a percutaneous drain to facilitate lung abscess drainage
2018
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Overview
This is a case of primary pulmonary lymphoma presenting concurrently with superimposed lung abscess, managed with the assistance of intracavitary fibrinolytic therapy. A 28-year-old man presented with 2 months of persistent cough. He had a large lung abscess involving almost the entire right upper lobe. The mass continued to progress in spite of appropriate antibiotic administration. Given the extent of involvement, he was not a surgical candidate. A bronchoscopy with bronchoalveolar lavage and transbronchial biopsies demonstrated diffuse large B cell lymphoma. Initial cultures were positive for Group G Streptococci. A CT-guided percutaneous drain was placed with initial purulent drainage that grew Prevotella and Streptococcus mitis; however, drainage quickly abated without adequate evacuation of the abscess cavity. To further optimise drainage in anticipation of chemotherapy administration, intracavitary fibrinolytic therapy including tissue plasminogen activator and deoxyribonuclease was attempted to better evacuate the infected space.
Publisher
BMJ Publishing Group LTD,BMJ Publishing Group
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